Neuropsychological deficits associated with route learning in Alzheimer disease, MCI, and normal aging.

Background: The background of route learning (RL) abilities in Alzheimer disease (AD), mild cognitive impairment (MCI), and normal aging needs further study. We searched for neuropsychological and demographical predictors of RL impairment.

Methods: RL was investigated in a clinical study including subjects classified as early AD (n=37), MCI (n=34), and aged normal controls (n=46).