Publications by authors named "Sigrid Baars"
Article Synopsis
- The development of the nervous system involves various cell-to-cell communication methods that help neurons and axons navigate and form complex networks, but the coordination of these processes is not well understood.
- Cross-regulatory interactions and redundancy in signaling pathways can enhance the precision of these guidance systems.
- L1CAM, an immunoglobulin superfamily protein, physically interacts with erbB receptors, which boosts their responsiveness to neuregulins during neuron development and may help target specific cells or axons that engage with L1CAM.
L1- and NCAM-type cell adhesion molecules represent distinct protein families that function as specific receptors for different axon guidance cues. However, both L1 and NCAM proteins promote axonal growth by inducing neuronal tyrosine kinase activity and are coexpressed in subsets of axon tracts in arthropods and vertebrates. We have studied the functional requirements for the Drosophila L1- and NCAM-type proteins, Neuroglian (Nrg) and Fasciclin II (FasII), during postembryonic sensory axon guidance.
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