Propofol-induced injection pain: comparison of a modified propofol emulsion to standard propofol with premixed lidocaine.

Propofol is well known for its association with pain on injection. The most frequently used method to reduce this pain is premixture with lidocaine. Recently, a modified lipid emulsion of propofol containing medium-chain triglycerides (MCT) with long-chain triglycerides (LCT), in contrast to the usual LCT formulation, has been advocated to alleviate pain.

Propofol in a medium- and long-chain triglyceride emulsion: pharmacological characteristics and potential beneficial effects.

Unlabelled: Hypertriglyceridemia is a possible unwanted effect during long-term propofol sedation while using a formulation containing long-chain triglycerides (LCT) from soybean oil. The use of propofol formulated in a solvent consisting of medium-chain triglycerides (MCT) and LCT might reduce the risk. Because a new solvent may affect the pharmacological profile of propofol, in this prospective, randomized, controlled, and double-blinded study we compared the pharmacodynamic and kinetic characteristics of propofol diluted in MCT/LCT fat solution with those of propofol formulated in LCT fat emulsion.

Progressive electroencephalogram frequency deceleration despite constant depth of propofol-induced sedation.

Objective: To investigate a possible time-dependent effect of propofol sedation on electroencephalographic activity, we analyzed the electroencephalogram frequency behavior while keeping patients at a constant level of sedation.

Design: Prospective, controlled trial.

Setting: Intensive care unit of a university hospital.