Publications by authors named "Signore A"

In the context of climate change, reducing the environmental impact of agriculture has become increasingly critical. To ensure sustainable food production, it is essential to adopt cultivation techniques that maximize resource efficiency, particularly in water and nutrient usage. The Nutrient Film Technique (NFT) is one such hydroponic system, designed to optimize water and nutrient use, making it a valuable tool for sustainable agriculture.

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Wild birds are important hosts of influenza A viruses (IAVs) and play an important role in their ecology. The emergence of the A/goose/Guangdong/1/1996 H5N1 (Gs/GD) lineage marked a shift in IAV ecology, leading to recurrent outbreaks and mortality in wild birds from 2002 onwards. This lineage has evolved and diversified over time, with a recent important derivative being the 2.

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Avian influenza viruses (AIVs) regularly circulate between wild and domestic bird populations. Following several high-profile outbreaks, highly pathogenic AIVs (HPAIV) with zoonotic potential have been the subject of increasing attention. While we know that HPAIV is transmitted between domestic birds, wildlife, and the environment, little is known about persistence and spillover/back at these interfaces.

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Background: Preoperative review of computed tomography (CT) imaging assists with endoscopic sinus surgery (ESS) planning, where trainees may benefit from a systematic approach. We have previously developed an optimized preoperative checklist for sinus CT imaging using an iterative modified Delphi method.

Objective: In this study, we assess the utility of an optimized preoperative checklist for residents performing ESS.

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Article Synopsis
  • - Hybrid [F]FDG PET imaging is the preferred method for diagnosing infectious and inflammatory disorders, with recent updates in clinical guidelines reflecting a surge in evidence-based research since 2013.
  • - The aim of the updated guidelines is to furnish physicians with current, evidence-based knowledge to effectively conduct and interpret hybrid [F]FDG PET scans in adult patients.
  • - A systematic literature review revealed that hybrid [F]FDG PET is highly effective for managing these conditions, although monitoring treatment response remains a challenging area due to limited research.
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White blood cell (WBC) scintigraphy plays a major role in the diagnostic approach to periprosthetic infections. Although the procedure has been standardized by the publication of several guidelines, the interpretation of this technique may be susceptible to intra and inter-variability. We aimed to assess the reproducibility of interpretation between nuclear medicine physicians and by the same physician and to demonstrate that Cohen's coefficient is more unstable than Gwet's coefficient, as the latter is influenced by the prevalence rates.

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Article Synopsis
  • Mammalian cardiac troponin I (cTnI) has an amino-terminal extension with serine targets that get phosphorylated to improve heart relaxation during increased heart activity.
  • Researchers found that some species like shrews and moles evolved to mimic this phosphorylation process, allowing them to maintain extremely high resting heart rates.
  • The study suggests that humans could improve heart function in heart failure by considering the removal of a weakly spliced exon found in cTnI, which has implications for heart health.
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Cascade cropping systems (CCS) utilize leachate from a primary crop to grow secondary crops and enhance the efficient use of water and fertilizers in areas with scarce water resources. A preliminary study investigated the effect of melatonin in a cascade cropping system to potentially improve plant tolerance to abiotic stresses. This study aimed to cultivate in this cropping system to reduce nutrient discharge and assess the impact of exogenous melatonin on Salicornia growth and quality.

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Chronic rhinitis substantially impacts a person's quality of life. We evaluated a novel, multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. This was a prospective, multicenter, single-arm clinical study of posterior nasal nerve ablation in adults with chronic rhinitis.

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Objectives: To discriminate between post-treatment changes and tumor recurrence in patients affected by glioma undergoing surgery and chemoradiation with a new enhancing lesion is challenging. We aimed to evaluate the role of ASL, DSC, DCE perfusion MRI, and 18F-DOPA PET/CT in distinguishing tumor recurrence from post-treatment changes in patients with glioma.

Materials And Methods: We prospectively enrolled patients with treated glioma (surgery plus chemoradiation) and a new enhancing lesion doubtful for recurrence or post-treatment changes.

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Article Synopsis
  • Following the detection of a novel highly pathogenic avian influenza virus (HPAIV) H5N1 in Newfoundland in late 2021, Canada ramped up surveillance efforts of wild birds to track the spread of the virus nationwide.* -
  • During the first year of surveillance (November 2021-November 2022), over 6,000 sick and dead birds were tested, revealing that 27.4% were positive for HPAIV across various species and regions, particularly in the Atlantic and Central Flyways.* -
  • The findings highlighted the need for ongoing monitoring and collaboration, as wild birds serve as both victims and reservoirs of the virus, with a notable prevalence of Eurasian-origin strains identified throughout
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This follow-up dual-institutional and longitudinal study further evaluated for underlying gender biases in LORs for rhinology fellowship. Explicit and implicit linguistic gender bias was found, heavily favoring male applicants.

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Highly pathogenic avian influenza (HPAI) viruses have spread at an unprecedented scale, leading to mass mortalities in birds and mammals. In 2023, a transatlantic incursion of HPAI A(H5N5) viruses into North America was detected, followed shortly thereafter by a mammalian detection. As these A(H5N5) viruses were similar to contemporary viruses described in Eurasia, the transatlantic spread of A(H5N5) viruses was most likely facilitated by pelagic seabirds.

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Objectives: Virtual reality (VR) and augmented reality (AR) are innovative technologies that have a wide range of potential applications in the health care industry. The aim of this study was to investigate the body of research on AR and VR applications in rhinology by performing a scoping review.

Data Sources: PubMed, Scopus, and Embase.

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Background: Improved nasal airway obstruction (NAO) symptoms were reported at 3 months following temperature-controlled radiofrequency (TCRF) treatment of the septal swell body (SSB). This report provides results from assessments of the long-term safety and efficacy of TCRF treatment of SSB hypertrophy to treat NAO through 12 months posttreatment.

Methods: This prospective, multicenter, long-term, open-label study was conducted in nine centers within the United States and included patients with severe/extreme NAO attributed to SSB hypertrophy.

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We describe an unusual mortality event caused by a highly pathogenic avian influenza (HPAI) A(H5N1) virus clade 2.3.4.

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Purpose: Gastroenteropancreatic -neuroendocrine tumours (GEP-NETs) are commonly treated with surgical resection or long-term therapies for tumour growth control. Lutetium [Lu]-DOTA-TATE was approved for the treatment of GEP-NETs after the phase III NETTER 1trial demonstrated improved progression free survival, objective response rates and health-related quality of life (HRQoL) compared to high-dose somatostatin analogues. No real-world data exist on prescribing habits and clinically significant endpoints for [Lu]Lu-DOTA-TATE treatment in Italy.

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Unlabelled: Tumor associated fibroblasts (TAFs) play a key role in tumor growth and metastatization. TAFs overexpress different biomarkers that are usually expressed at low levels in physiological conditions. Among them are the fibroblast growth factor receptors (FGFRs) that bind the fibroblast growth factors (FGFs).

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Purpose: To evaluate the marginal integrity of three inlay-retained fixed dental prosthesis (IRFDP) designs fabricated using monolithic zirconia.

Materials And Methods: In total, 30 IRFDPs were fabricated using 4-YTZP monolithic zirconia and randomly divided into three groups according to the cavity design. Groups ID2 and ID1.

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This systematic review, conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, aims to comprehensively assess the current state of the art of imaging modalities for the evaluation of peritoneal carcinomatosis arising from malignant gynecological origins, with a focus on ovarian and endometrial cancers. A systematic search of relevant databases was performed, adhering to predetermined inclusion and exclusion criteria. Studies reporting the use of computed tomography (CT), magnetic resonance imaging (MRI), fluorodeoxyglucose (FDG) positron emission tomography (PET), PET/CT, and PET/MRI in the assessment of peritoneal carcinomatosis from gynecological malignancies were included.

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Article Synopsis
  • The document outlines evidence-based recommendations for the best imaging strategies to evaluate diabetic foot complications, focusing on both infective and non-infective cases.
  • A group of experts, including nuclear medicine physicians and clinicians, formulated clinical questions related to diabetic foot that current guidelines do not fully address, using a systematic analysis of existing literature.
  • Seven key recommendations were made, emphasizing the need for advanced imaging techniques like MRI and WBC scintigraphy, while noting the lack of definitive preferences for imaging modalities in detecting osteomyelitis in the foot.
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Background: The 24-month clinical performance of 3 commercially available flowable bulk-fill resin composites in Class III restorations was evaluated.

Material And Methods: Forty-two patients, 27 females (64.3%) and 15 (35.

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Purpose: To compare the fracture load of two framework materials, zirconia and a new fiber-reinforced composite (FRC), for full-arch implant-supported rehabilitations using various cross- sections.

Material And Methods: A cobalt-chromium metal model simulating the all-on-four concept and including 2 anterior straight and 2 posterior 45- degree angled multi-unit digital implant analogs was manufactured. 4 straight multi-unit abutments were screwed onto the implant analogs.

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