Publications by authors named "Signem Eyuboglu"
Maintenance of body temperature within physiological range is critical for the fetal and neonatal development. Hyperthermia is one of the most frequently encountered pediatric complaints and may cause neurological disorders due to neuronal injury. In this study, we aimed to investigate the effects of hyperthermia on behavioral alterations, neuronal survival, apoptosis, and cell proliferation in young male Sprague-Dawley rats.
View Article and Find Full Text PDFPersistent organic pollutants (POPs) continue to threaten the environment and human health. We have investigated levels of polychlorinated biphenyls (PCBs) and organochlorinated pesticides (OCPs) in breast milk samples. A questionnaire was also obtained from the study participants.
View Article and Find Full Text PDFPurpose: To compare the inhibitory effects of dovitinib and bevacizumab for treatment of corneal neovascularization (CNV).
Methods: Thirty-nine adult female Sprague Dawley rats weighing 180 to 250 g were used. CNV was induced by silver nitrate in the right eye of each rat.
Purpose: We aimed to compare the neuroprotective effects of brimonidine tartrate (BRT) and melatonin (MEL) on retinal ganglion cells (RGCs) in a rat glaucoma model.
Methods: Thirty-six adult Wistar albino rats were allocated into six groups: control (C), glaucoma (G), BRT, MEL, G + BRT and G + MEL. After establishing the glaucoma model, intraocular pressure (IOP) of all animals measured at day 4 and day 30 was compared statistically with day 0 and day 4, respectively.
Article Synopsis
- - The study investigates how kisspeptin-10 affects structural damage in testicle tissue of young rats caused by methionine-induced lipid peroxidation, which disrupts the balance of oxidants and antioxidants.
- - Results showed that while kisspeptin-10 did not significantly impact spermatogenic cells, it led to increased catalase and superoxide dismutase enzyme activity, suggesting potential protective effects against damage.
- - Additionally, methionine exposure decreased testosterone and luteinizing hormone levels, but the changes were not always statistically significant, highlighting kisspeptin's role in mitigating spermatogenic cell damage.
Effects of the gonadotropin-releasing hormone antagonist cetrorelix in the early postimplantation period on rat pregnancy.
Eur J Obstet Gynecol Reprod Biol
April 2011
Objective: The effect of cetrorelix given in the early implantation period on rat pregnancy was investigated.
Study Design: Forty-nine virgin Sprague-Dawley rats were randomized into six groups. At the 4th or 8th days of sperm plug, groups received 15, 75, 150 μg/kg cetrorelix or saline.