Total population-based study of the impact of substance use disorders on the overall survival of psychiatric inpatients.

Background: Patients with severe mental illness have a shortened lifespan, and substance use disorder (SUD) is an especially important diagnosis in this respect. There have been no studies comparing directly SUD to other diagnoses in a nationwide cohort.

Aims: To directly compare differences in mortality rates of psychiatric inpatients with a discharge diagnosis of SUD versus other psychiatric diagnoses.

The changing gender gap in substance use disorder: a total population-based study of psychiatric in-patients.

Aims: To study changes over a 25-year period in the gender gap in discharge diagnoses of alcohol use disorder (AUD) and other substance use disorder (SUD) in psychiatric in-patients.

Design, Setting And Participants:  A register-based study of all admissions to psychiatric hospitals in Iceland between January 1983 and December 2007.

Measurements: Annual rate of admissions to psychiatric hospitals, adjusted for changes in the size of the population.

Neuregulin 1 and susceptibility to schizophrenia.

The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding components of these systems.