Effect of oral imperatorin on memory in mice.

The aim of this study was to explore the effect of the acetylcholinesterase inhibiting mixture of extracts of Angelica archangelica fruit and Geranium sylvaticum on memory. Furthermore the effect of the main compound, the furanocoumarin imperatorin, which has been shown to affect several neurotransmitters, was studied. Passive avoidance was measured by step-down latency and step-through latency of 10 months old mice receiving 0.

A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men.

Objective: This study aimed to investigate the effect of SagaPro, a product derived from Angelica archangelica leaf, on nocturia.

Material And Methods: Sixty-nine male patients 45 years or older with at least two nocturnal voids were randomized to receive SagaPro or placebo in a double-blind design for 8 weeks. Voiding diaries were assessed before and after the treatment.

Geographical variation of the furanocoumarin composition of the fruits of Icelandic Angelica archangelica.

Angelica archangelica fruits were collected from 64 locations around Iceland and analysed for furanocoumarins by high-performance liquid chromatography. The average furanocoumarin content was found to be 22.5 mg/g, ranging from 14.

Inhibition of acetylcholinesterase by extracts and constituents from Angelica archangelica and Geranium sylvaticum.

The aim of this study was to explore the acetylcholinesterase (AChE) inhibition of several Icelandic medicinal herbs. Ethanolic extracts of Angelica archangelica seeds and the aerial parts of Geranium sylvaticum proved effective, with IC50 values of 2.20 mg/ml and 3.

The cytotoxic effect of two chemotypes of essential oils from the fruits of Angelica archangelica L.

Background: The aim of this work was to study the constituents and cytotoxicity of the essential oils from the fruits of Angelica archangelica growing in Iceland.

Materials And Methods: Three samples of essential oils were prepared by steam distillation. Their composition was established with GC/MS.

Antiproliferative effect of Angelica archangelica fruits.

The aim of this work was to study the antiproliferative effect of a tincture from fruits of Angelica archangelica and the active components using the human pancreas cancer cell line PANC-1 as a model. Significant dose-dependent antiproliferative activity was observed in the tincture with an EC50 value of 28.6 microg/ml.

Antitumour activity of Angelica archangelica leaf extract.

Background: The purpose of this study was to examine the effect of a leaf extract from A. archangelica on the growth of Crl mouse breast cancer cells in vitro and in vivo.

Materials And Methods: The antiproliferative activity of the extract was measured by 3H-thymidine uptake in the Crl cells in vitro.

Sphingosine modulation of cAMP levels and beating rate in rat heart.

Sphingolipids, especially as elements of the sphingomyelin signal transduction cycle, are thought to play a significant role as second messengers and modulators of events in heart muscle cells. A possible modulatory role of sphingosine in signal transduction in the beta-adrenergic pathway in the heart was examined. Neonatal rat cardiomyocytes were incubated with sphingosine and/or other agents after which cAMP levels and contraction rates were measured.