Concentrated growth factor intradermal injection assisted super-thin flap expansion for repairing skin defects: A randomized, single blinded, split-site study.

Background: The super-thin skin flap formed by skin and soft tissue expansion has large area and good ductility, so it can be used to repair skin defects. However, because the flap is thin, the blood flow in the dermis of the super-thin expanded flap is weakened, and flap rupture and necrosis after secondary flap transfer may occur.

Objective: To compare the skin thickness difference between the expanded ultrathin flaps injected with concentrated growth factor (CGF) and the blank group or saline group.

Comparative efficacy and safety of tranexamic acid for melasma by different administration methods: A systematic review and network meta-analysis.

Background: Tranexamic acid (TA) is a new and promising drug for the treatment of melasma.

Objectives: This network meta-analysis aims to compare the efficacy and safety of various ways of administration of TA on melasma.

Methods: We collected researches from PubMed, EMBASE, Cochrane Library and Web of Science.

Potential Resistance to Antineoplastic Aminated Fullerenes Mediated by M2-Like Monocyte-Derived Exosomes.

Exosomes are small extracellular vesicles critical for intercellular signaling their delivery of cargoes, including proteins, DNA, RNA, lipids, and metabolites. Exosomes play essential roles in remodeling the tumor microenvironment (TME) for tumor growth, metastasis, and drug resistance. Aminated fullerenes (e.

Diketopyrrolopyrrole-Based Conjugated Polymer Entailing Triethylene Glycols as Side Chains with High Thin-Film Charge Mobility without Post-Treatments.

Side chain engineering of conjugated donor-acceptor polymers is a new way to manipulate their optoelectronic properties. Two new diketopyrrolopyrrole (DPP)-terthiophene-based conjugated polymers PDPP3T-1 and PDPP3T-2, with both hydrophilic triethylene glycol (TEG) and hydrophobic alkyl chains, are reported. It is demonstrated that the incorporation of TEG chains has a significant effect on the interchain packing and thin-film morphology with noticeable effect on charge transport.

Pre-expanded Super-Thin Skin Perforator Flaps.

Patients with severe postburn scar contractures underwent reconstruction of skin defects after scar excision with pre-expanded super-thin skin perforator flaps supplied primarily by perforators via the "bridging effect" from the branches of the adjacent arteries as 2-stage procedures. Pre-expansion is an innovative technique and may improve the anastomoses between subdermal vascular plexuses and extend the supplying area of these vessels to the flap. Such a flap becomes super thin, but with a prefabricated blood supply it can be used for reconstruction of skin defects of the face, neck, or other body part with improved functional and cosmetic outcomes.

Pre-expanded and Prefabricated Abdominal Superthin Skin Perforator Flap for Total Hand Resurfacing.

Reconstruction of the postburn hand remains a challenge for surgeons. For cosmetic and functional requirements, the desired flap should be thin enough to ensure the flexibility of the hand. Conventional perforator flaps serve as a viable option when reconstructing the postburn hand to regain functionality.

An Overview of Pre-expanded Perforator Flaps: Part 1, Current Concepts.

Pre-expanded perforator flaps, a combination of tissue expansion with perforator flaps, are emerging as another landmark of plastic surgery. This flap inherits the characteristics of both perforator flaps and expanded flaps, making it a highly versatile option in reconstructive surgery. However, the definition of the pre-expanded perforator flap and the impact of pre-expansion on the superficial angio-architecture remain controversial.

Thieno[3,4-c]Pyrrole-4,6-Dione and Dithiophene-Based Conjugated Polymer for Organic Field Effect Transistors: High Mobility Induced by Synergic Effect of H-Bond and Vinyl Linkage.

Here, a conjugated polymer VTTPD based on thieno[3,4-c]pyrrole-4,6-dione (TPD) and dithiophene with vinyl as linker is synthesized and characterized. Electrochemical and optical studies indicate the LUMO and HOMO energies of the polymer are -3.70 and -5.

The Clinical Application of Preexpanded and Prefabricated Super-Thin Skin Perforator Flap for Reconstruction of Post-Burn Neck Contracture.

Objective: Based on our previous animal study, we applied the "bridging effect" to the neighboring axial flap through preexpansion and prefabrication of a skin perforator flap as a new method to reconstruct a large skin defect after release of severe neck burn scar contracture.

Methods: Twelve patients suffering from severe post-burn cervical contractures underwent reconstruction of large skin defects after surgical release of severe scar contractures with preexpanded and prefabricated super-thin skin perforator flaps supplied primarily by a number of perforators via the "bridging effect" from the branches of the adjacent arteries as 2-stage procedures. During the first-stage operation, 2 tissue expanders were placed accordingly, and this was followed by a subsequent second-stage procedure where an expanded super-thin skin perforator flap was transposed to reconstruct a large neck skin defect.

The Value of Multidetector Row Computed Tomography Angiography for Preoperative Planning of Freestyle Pedicled Perforator Flaps.

Background: Because the course and territory of perforators are different in each region, careful preoperative planning to identify the proper perforators can be critical to ensure a successful dissection of a freestyle pedicled perforator flap. In this study, our first experience for preoperative perforator mapping of a freestyle pedicled perforator flap using multidetector row computed tomography (MD-CT) angiography is presented.

Methods: Twelve patients were planned to undergo various soft-tissue reconstructions with freestyle pedicled perforator flaps.

Thiepin-fused heteroacenes: simple synthesis, unusual structure, and semiconductors with less anisotropic behavior.

The simple one-pot syntheses of sulfur-rich thiepin-fused heteroacences with an alkylidene-fluorene framework, THA1 and THA6 (thiepin-fused heteroacene 1 or 6, in which the thiepin is conjugated at both ortho positions with SCH3 or SC6 H13 , respectively), is reported. Based on electrochemical studies and theoretical calculations, their LUMO energies are relatively low (-3.26 eV), and their HOMO and HOMO-1 orbitals are nearly degenerate.

Simple bipolar molecules constructed from biphenyl moieties as host materials for deep-blue phosphorescent organic light-emitting diodes.

Simple is good! Based on biphenyl molecules, two bipolar host materials with high triplet energies have been rationally designed, synthesized, and fully characterized. Deep blue phosphorescent organic light-emitting diodes, which employ the new hosts and an iridium(III) complex as triplet emitter, show a maximum current efficiency of 40 cd A(-1), a maximum power efficiency of 36 lm W(-1), and a maximum external quantum efficiency of 19.5 %.