Metabolomics as an emerging tool for the pharmacological and toxicological studies on Aconitum alkaloids.

Aconitum (Ranunculaceae) has a long-standing history in traditional Chinese medicine (TCM), where it has been widely used to treat conditions such as rheumatoid arthritis (RA), myocardial infarction, and heart failure. However, the potency of Aconitum alkaloids, the primary active components of Aconitum, also confers substantial toxicity. Therefore, assessing the efficacy and toxicity of these Aconitum alkaloids is crucial for ensuring clinical effectiveness and safety.

Response to the Comment on "Text-to-Video Models and Sora in Plastic Surgery: Pearls, Pitfalls, and Prospectives".

The objective of this paper is to respond to the comment regarding "Text-to-Video Models and Sora in Plastic Surgery: Pearls, Pitfalls, and Prospectives" and to provide further explanation on the opinions discussed therein. The emergence of text-to-video models, like Sora, allows us to see more vivid examples of artificial intelligence applied to life. The development of new technologies, like text-to-video models, needs to be recognized, questioned, regulated, and upgraded.

TPMGD: A genomic database for the traditional medicines in Pakistan.

Objective: In Pakistan, traditional medicines are an important component of the medical system, with numerous varieties and great demands. However, due to the scattered resources and the lack of systematic collection and collation, adulteration of traditional Pakistani medicine (TPM) is common, which severely affects the safety of their medicinal use and the import and export trades. Therefore, it is urgent to systematically organize and unify the management of TPM and establish a set of standards and operable methods for the identification of TPM.

Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation.

Aberrant autophagy in vascular smooth muscle cells (VSMCs) is associated with the progression of vascular remodeling diseases caused by neointimal hyperplasia. Platelet-derived growth factor-BB (PDGF-BB)-induced vascular remodeling is accompanied by autophagy activation, however, the involvement of circular RNAs (circRNAs) remains unclear. Here, we show the role of PDGF-BB-regulated hsa_circ_0001304 (circ-1304) in neointimal hyperplasia and its potential involvement in VSMC autophagy, while also elucidating the potential mechanisms.

Global research trends in the teacher evaluation of medical college: A bibliometric and visualized study.

Background: The evaluation of education in colleges and universities is not only an essential means to promote teachers' professional development and ensure high-quality development of education but also a strong support for the overall development of colleges and universities. In this study, to understand the development trends and predict the future of teacher evaluation in medical colleges from 2005 to 2023, we conducted a comprehensive bibliometric and visualized study using Web of Science.

Methods: The articles on teacher evaluation in medical colleges were extracted from the "Core Collection" of the WoS database.

Text-to-Video Models and Sora in Plastic Surgery: Pearls, Pitfalls, and Prospectives.

After the groundbreaking release of the highly acclaimed chatbot ChatGPT, which revolutionized the field of artificial intelligence (AI) last year, OpenAI has once again astounded the world with the unveiling of their latest generative AI model, Sora, on February 16, 2024. This cutting-edge model has the remarkable ability to generate videos up to a duration of 60 seconds solely through text instructions. With a series of AI-generated contents, such as AI chat, AI drawing, and AI music, emerging one after another, the era of "AI revolution" that had a disruptive impact on modern life has arrived.

Occurrence and Genotypic Identification of spp. and in Bamaxiang Pigs in Bama Yao Autonomous County of Guangxi Province, China.

spp. and are common intestinal pathogens capable of infecting both humans and animals, which lead to severe diarrhea and other intestinal diseases, posing a threat to public health. The Bamaxiang pig, a specialty of Bama Yao Autonomous County in Guangxi Province, China, is an important local breed in the regional pork market and an excellent model animal for biomedical research.

Oxidative and endoplasmic reticulum stress in diabetes-related hearing loss: Protective effects of thioredoxin.

Diabetes mellitus (DM) induces complex physiological changes in the inner ear environment. This study investigates the roles of oxidative stress (OS) and endoplasmic reticulum stress (ERS) in diabetes-related hearing loss (DRHL) and explores the potential of thioredoxin (Trx) in regulating OS, ERS, and apoptosis-related factors to mitigate the progression of hearing impairment. We conducted auditory and serological assessments in 63 patients with type 2 diabetes and 30 healthy controls.

Depressive disorders in Chinese left-behind children and adolescents from Yunnan province: prevalence and association with self-harm behaviors.

Background: The prevalence of clinically diagnosed depressive disorders (DD) in Chinese left-behind children (LBC) remains unknown. We aim to estimate the prevalence of DD, discuss the associations between DD and self-harm (SH) behaviors in a large representative sample of Chinese LBCs chosen from Yunnan province.

Methods: A total of 5462 LBCs were selected from the most recent datasets of the Mental Health Survey for Children and Adolescents in Yunnan (MHSCAY), a mega population-based two-phase cross-sectional survey.

Quantification and visual inspection of adipic dihydrazide in textile using a xanthylium-based ratiometric fluorescent probe.

Residual adipic dihydrazide (ADH) in textiles may react with formaldehyde to form hydrazone, which is a source of the formaldehyde pollutant indoors. In this paper, a xanthylium-based ratiometric fluorescent probe SH-Py was developed for ADH detection. The emission of SH-Py at 680 nm decreased, whereas that at 463 nm increased upon the addition of ADH in pure DMSO.

The systemic treatments for drug reaction with eosinophilia and systemic symptoms (DRESS) beyond corticosteroids.

Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DiHS), is a severe type of cutaneous adverse reaction. The gold standard therapy for DRESS involves the discontinuation of the culprit drug, supportive therapies, and administration of corticosteroids. However, in cases of primary treatment failure or suboptimal response, there arises an urgent need for alternative interventions.

Ultrafast DNA detection based on turn-back loop primer-accelerated LAMP (TLAMP).

Rapid DNA detection is a long-pursuing goal in molecular detection, especially in combating infectious diseases. Loop-mediated isothermal amplification (LAMP) is a robust and prevailing DNA detection method in pathogen detection, which has been drawing broad interest in improving its performance. Herein, we reported a new strategy and developed a new LAMP variant named TLAMP with a superior amplification rate.

Serum Globulin to Albumin Ratio as a Novel Predictor of Adverse Clinical Outcomes in Coronary Artery Disease Patients Who Underwent PCI.

Background: Coronary heart disease is one of the main causes of Mortality. Many biological indicators have been used to predict the prognosis of patients with coronary heart disease. The ratio of serum globulin to albumin (GAR) has been used to predict the prognosis of patients with various cancers.

Predictive Value of the Fibrinogen to Gamma-Glutamine Transferase Ratio in the Long-Term Outcome in Patients with Coronary Heart Disease: A Retrospective Cohort Study.

Background: The ratio of fibrinogen to -glutamine transferase (FGR) was used to predict long-term prognosis in patients with coronary heart disease (CHD).

Methods: A total of 5638 patients with CHD who were hospitalized from January 2008 to December 2016 were retrospectively enrolled in the study. The mean follow-up time was 35.

[Estrogen receptor Esr1 induces early ovarian differentiation in ].

This study aims to explore the roles of three estrogen receptors (Esr1, Esr2, and Gper1) in early differentiation of embryonic gonads of . The expression characteristics of the receptor genes were studied first. The Esr1, Esr2, and Gper1 agonists PPT, WAY 200070, and G-1 were respectively injected into the embryos at the male-producing temperature (MPT) before initiation of gonadal differentiation.

Fast detection of sodium dithionite in sugar using a xanthylium-based fluorescent probe.

Dithionite remained in the foodstuff may pose a great threat to the health of consumers. Three xanthylium-based probes were synthesized and their responses to dithionite were explored. Probe SH-1 could respond to dithionite selectively in PBS buffer (15% DMSO, 10 mM, pH = 7.

Constricted posterior fourchette deformities: Definition, classification and surgical treatment.

Background: Labiaplasty is one of the top cosmetic procedures patients are seeking in the past two years. However, treatment of disease in posterior fourchette caused by various etiological factors was less investigated and neglected.

Methods: Three types of posterior fourchette deformity were proposed: (1) Redundant posterior fourchette, (2) Relaxed posterior fourchette, and (3) Constricted posterior fourchette.

Learning Only on Boundaries: A Physics-Informed Neural Operator for Solving Parametric Partial Differential Equations in Complex Geometries.

Recently, deep learning surrogates and neural operators have shown promise in solving partial differential equations  (PDEs). However, they often require a large amount of training data and are limited to bounded domains. In this work, we present a novel physics-informed neural operator method to solve parameterized boundary value problems without labeled data.

Synthesis of sulfinamides photocatalytic alkylation or arylation of sulfinylamine.

Sulfinamides are a versatile class of compounds that find applications in both organic synthesis and pharmaceuticals. Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. Commercially available potassium trifluoro(organo)borates and readily available sulfinyl amines are rationally used and converted to a series of alkyl or aryl sulfinamides in moderate to high yields.

Effectiveness of lipid-lowering therapy on mortality and major adverse cardiovascular event outcomes in patients undergoing percutaneous coronary intervention: a network meta-analysis of randomised controlled trials.

Background: Emergency percutaneous coronary intervention (PCI) can quickly restore myocardial perfusion after acute coronary syndrome. Whether and which lipid-lowering regimens are effective in reducing major adverse cardiovascular events (MACEs) and mortality risk after PCI remain unclear.

Objective: This study assessed the benefits of different lipid-lowering regimens on the risk of MACEs and mortality in the post-PCI population by network meta-analysis.