Publications by authors named "Sifan Shangguan"
Article Synopsis
- 2-Decenoic acid is an important fatty acid used in pharmaceuticals and is now being produced more efficiently, but its production is hindered by oxidative stress from high concentrations of fatty acids.
- Researchers improved production by redesigning the electron transport chain and reducing reactive oxygen species (ROS) levels through genetic modifications and inhibitors like rotenone.
- The modified strain led to a 93.33% increase in -2-decenoic acid yield, achieving the highest reported yield of 1.45 g/L, demonstrating a successful approach to enhance fatty acid biosynthesis.
is a eukaryotic organism with a clear genetic background and mature gene operating system; in addition, it exhibits environmental tolerance. Therefore, is one of the most commonly used organisms for the synthesis of biological chemicals. The investigation of fatty acid catabolism in is crucial for the synthesis and accumulation of fatty acids and their derivatives, with β-oxidation being the predominant pathway responsible for fatty acid metabolism in this organism, occurring primarily within peroxisomes.
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