Immunofluorescence in situ and the serologic indices of Chlamydia pneumoniae infection in patients with an abdominal aortic aneurysm.

The aim of the study was to evaluate the frequency of Chlamydia pneumoniae infection in patients with abdominal aortic aneurysm (AAA) using selected methods. The histological specimens of aneurysm wall were evaluated, the method of immunofluorescence was used to reveal the antigen in the wall of AAA and the titers of specific antibodies of IgG, IgM and IgA classes in blood plasma were marked. Atherosclerotic changes in the aneurysm wall were found in all patients.

Embryofetotoxicity of acetaminophen (paracetamol) in experimental in vivo model.

The aim of the study was to evaluate the toxic effect of acetaminophen on rat fetuses. Acetaminophen, suspended in Tween 80 solution, was administered once a day, orally by a stomach tube to pregnant Wistar rats from day 8th to 14th of pregnancy at the dose: 3.5 (P1), 35.

Pathophysiologic role of oxygen-free radicals in toxic damage of the liver.

The role of oxidative stress in toxic injury of the liver has been well documented. Molecular oxygen is indispensable for most of the living organisms but under specific conditions can be cytotoxic for all organisms. If oxygen concentration will be higher than its amount in the atmosphere, different pathological processes can occur in aerobic organisms.

Free radicals-induced morphological changes in the pancreas.

Oxidative stress occurs whenever there is an imbalance between the generation of free radicals and the antioxidant defense. Oxygen is cytotoxic if oxygen concentration is higher than its amount in the atmosphere. This phenomenon is called hyperoxide process.

Histoclinic of the abdominal aortic aneurysms.

The aim of this study was to analyze the scientific protocol of 21 patients operated due to abdominal aortic aneurysm. Arterial hypertension was the common feature for the whole group. Typical microscopic changes for true aortic aneurysm in all histopathological findings were approved.

Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver.

The common effects of acetaminophen (APA), isopropylantipyrine (IPA) and caffeine on liver were examined in rats. The preparations were given in Tween-80 solution once daily, in a constant proportion of 5:3:1, during days 8 to14 of gestation (S1, S2, S3 groups) or between days 8 and 14 of the experiment in nonpregnant female Wistar rats (S1-NP, S2-NP, S3-NP groups). The administration was in three different doses: doses S1, S1-NP-3.

Hepatic lysosomal enzymes activity and liver morphology after short-time omeprazole administration.

The aim of the study was to establish the influence of short-time omeprazole administration on liver function and morphology. Omeprazole was administered intraperitoneally, twice daily, for 3 days to male Wistar rats in two doses: 0.571 mg/kg and 5.

Temporary elevation of pancreatic lysosomal enzymes, as a result of the omeprazole-induced peripancreatic inflammation in male Wistar rats.

Omeprazole is one of the substituted benzimidazoles, which is not free of side effects. The aim of the study was to evaluate the influence of omeprazole therapy on pancreas. Omeprazole was administered intraperitoneally, twice a day, for 3 days to the male rats in 0.

Acute and chronic toxicity of "Polfa" perphenazine.

The toxicity of "Polfa" perphenazine and its profile of pharmacological properties were estimated. LD50 values calculated in rats were 2000 mg/kg and 325 mg/kg, after p.o.

Influence of lead acetate on the histological, ultrastructural and histochemical picture of the livers of albino rats.

The amount of lead pollution in the environment is increasing proportionally to the development of industry. Lead is capable of damaging the organism in many ways due to its high affinity to various tissues, different enzymes and serum proteins and its tendency to cumulate (1, 14). Acute lead poisoning occurs in people who have had intense, but short-term contact with organic lead compounds (tetraethylolead) used as an antidetonant in motor fuels, or plumbous orthoplumbate (red lead), which is an important component in anticorrosive paints (4, 6).

[Coexistence of sertolioma with borderline (adenoma-cystoma-fibroma) tumor in the ovaries of a 69 year old patient].

A rare case of coexistence of gonadal neoplasm Sertolioma with boundary line tumor with epithelial fill in ovaries in 69 old patient was described. Current diagnostic and prognostic possibilities in such cases were discussed.

Powdered diatrizoic acid for radiography of the respiratory tract. Part I. Experimental investigation.

Powdered diatrizoic acid as a contrast medium administered by inhalation and insufflation for visualization of the airways was tested in vitro and in 21 dogs. Good radiopacity of the contrast medium and its antibacterial activity was found in vitro. In the majority of animal experiments visualization of the bronchial tree down to segmental and partially to subsegmental bronchi with only minimal agglomeration of contrast medium and with good or very good demonstration of anatomic details was achieved.

[Carpal tunnel syndrome in hemodialysed patients].

A case of carpal tunnel syndrome in female patient treated with hemodialyses for 10 years is presented. Surgical management was applied with positive result. Histological examination of tissue collected during surgery has shown the deposits of amyloid-like substance in carpal tunnel.

Ultrastructure of the basilar artery in rabbit.

Ultrastructure of the basilar artery has been examined in 14 animals aged 70 and 140 days. The structure is characteristic for the muscular type artery. During the most intensive physical growth of the animals between 70 and 140 days, at the time of sexual maturation, the number of laminae in the middle layer increases from 4 to 6 and collagenous, and elastic fibers increase as well.

[Clinical, histopathologic, immunofluorescent and ultrastructural estimation of 2 cases of epidermolysis bullosa acquisita].

Two cases of EBA were presented. Both patients with the symptoms of the disease were previously treated with nonsteroid antiinflammatory drugs. A considerable improvement of the patients condition has been noticed after the application of high doses of glucocorticosteroids.

Comparison of pharmacological properties of rubidomycine and its newly synthesized derivatives DR-22 and DR-27 in animals.

The effect of two newly synthesized 5-amino modified analogues of rubidomycine was submitted to preliminary pharmacological and histological investigations in healthy Albino Swiss mice. The results showed a similarity of the tested properties of the new compounds and commercial rubidomycine, suggesting the same spectrum undesired side-effects after acute administration. Of the two novel compounds DR-22 was found to be less toxic, while much potent in its action on the haematopoietic system in comparison to rubidomycine, in prolonged treatment.