Universal monitoring of minimal residual disease in acute myeloid leukemia.

Background: Optimal management of acute myeloid leukemia (AML) requires monitoring of treatment response, but minimal residual disease (MRD) may escape detection. We sought to identify distinctive features of AML cells for universal MRD monitoring.

Methods: We compared genome-wide gene expression of AML cells from 157 patients with that of normal myeloblasts.

Spontaneous rupture with pseudoaneurysm formation in a nodular goiter presenting as a large neck mass.

Acute airway obstruction caused by goiter hemorrhage is a rare but potentially life-threatening condition. We report a case of nodular goiter in which spontaneous rupture with active bleeding developed suddenly, presenting as a large neck mass with dyspnea. Sonographic examination revealed a large inhomogeneous soft tissue mass in the left thyroid lobe containing some hypoechoic areas.

Ethnic differences in the frequency of subtypes of childhood acute lymphoblastic leukemia: results of the Malaysia-Singapore Leukemia Study Group.

Childhood acute lymphoblastic leukemia (ALL) is clinically heterogeneous with prognostically and biologically distinct subtypes. Although racial differences in frequency of different types of childhood ALL have been reported, many are confounded by selected or limited population samples. The Malaysia-Singapore (MA-SPORE) Leukemia Study Group provided a unique platform for the study of the frequency of major subgroups of childhood ALL in a large cohort of unselected multiethnic Asian children.

Primary small cell carcinoma of the pancreas with an unusual sonographic appearance.

We present a case of primary pancreatic small cell carcinoma with an unusual sonographic feature. A 75-year-old woman presented with poor appetite and weight loss. Abdominal sonographic examination revealed a diffusely enlarged pancreas with relative increased echogenicity and smooth contour.

Epiploic appendagitis of the rectosigmoid junction: demonstration with transrectal sonography.

A 24-year-old man presented with lower abdominal pain that had been present for 18 hours. Physical examination revealed mild tenderness in the lower abdomen. Digital rectal examination revealed a tender point approximately 9 cm above the anal verge.