The Quadrature Method: A Novel Dipole Localisation Algorithm for Artificial Lateral Lines Compared to State of the Art.

The lateral line organ of fish has inspired engineers to develop flow sensor arrays-dubbed artificial lateral lines (ALLs)-capable of detecting near-field hydrodynamic events for obstacle avoidance and object detection. In this paper, we present a comprehensive review and comparison of ten localisation algorithms for ALLs. Differences in the studied domain, sensor sensitivity axes, and available data prevent a fair comparison between these algorithms from their original works.

Three-dimensional multi-source localization of underwater objects using convolutional neural networks for artificial lateral lines.

This research focuses on the signal processing required for a sensory system that can simultaneously localize multiple moving underwater objects in a three-dimensional (3D) volume by simulating the hydrodynamic flow caused by these objects. We propose a method for localization in a simulated setting based on an established hydrodynamic theory founded in fish lateral line organ research. Fish neurally concatenate the information of multiple sensors to localize sources.

Recurrent neural networks for hydrodynamic imaging using a 2D-sensitive artificial lateral line.

The lateral line is a mechanosensory organ found in fish and amphibians that allows them to sense and act on their near-field hydrodynamic environment. We present a 2D-sensitive artificial lateral line (ALL) comprising eight all-optical flow sensors, which we use to measure hydrodynamic velocity profiles along the sensor array in response to a moving object in its vicinity. We then use the measured velocity profiles to reconstruct the object's location, via two types of neural networks: feed-forward and recurrent.

Bio-inspired all-optical artificial neuromast for 2D flow sensing.

We present the design, fabrication and testing of a novel all-optical 2D flow velocity sensor, inspired by a fish lateral line neuromast. This artificial neuromast consists of optical fibres inscribed with Bragg gratings supporting a fluid force recipient sphere. Its dynamic response is modelled based on the Stokes solution for unsteady flow around a sphere and found to agree with experimental results.

d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity.

Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial infections, but cause permanent hearing loss in a substantial proportion of treated patients. The sensory hair cells of the inner ear are damaged following entry of these antibiotics via the mechano-electrical transducer (MET) channels located at the tips of the hair cell's stereocilia. d-Tubocurarine (dTC) is a MET channel blocker that reduces the loading of gentamicin-Texas Red (GTTR) into rat cochlear hair cells and protects them from gentamicin treatment.

Performance of neural networks for localizing moving objects with an artificial lateral line.

Fish are able to sense water flow velocities relative to their body with their mechanoreceptive lateral line organ. This organ consists of an array of flow detectors distributed along the fish body. Using the excitation of these individual detectors, fish can determine the location of nearby moving objects.

The sensitivity of lateral line receptors and their role in the behavior of Mexican blind cavefish (Astyanax mexicanus).

The characid fish species Astyanax mexicanus offers a classic comparative model for the evolution of sensory systems. Populations of this species evolved in caves and became blind while others remained in streams (i.e.

Pairwise coupling of hair cell transducer channels links auditory sensitivity and dynamic range.

Hair cells in the inner ear provide the basis for the exquisite hearing capabilities of mammals. These cells transduce sound-induced displacements of their mechanosensitive hair bundle into electrical currents within a fraction of a millisecond and with nanometer fidelity. Excitatory displacements of the hair cell's bundle tense tip links that open transducer channels.

Mechanical filtering by the boundary layer and fluid-structure interaction in the superficial neuromast of the fish lateral line system.

A great diversity of aquatic animals detects water flow with ciliated mechanoreceptors on the body's surface. In order to understand how these receptors mechanically filter signals, we developed a theoretical model of the superficial neuromast in the fish lateral line system. The cupula of the neuromast was modeled as a cylindrical beam that deflects in response to an oscillating flow field.

The flexural stiffness of superficial neuromasts in the zebrafish (Danio rerio) lateral line.

Superficial neuromasts are structures that detect water flow on the surface of the body of fish and amphibians. As a component of the lateral line system, these receptors are distributed along the body, where they sense flow patterns that mediate a wide variety of behaviors. Their ability to detect flow is governed by their structural properties, yet the micromechanics of superficial neuromasts are not well understood.

Frequency-dependent properties of a fluid jet stimulus: calibration, modeling, and application to cochlear hair cell bundles.

The investigation of small physiological mechano-sensory systems, such as hair cells or their accessory structures in the inner ear or lateral line organ, requires mechanical stimulus equipment that allows spatial manipulation with micrometer precision and stimulation with amplitudes down to the nanometer scale. Here, we describe the calibration of a microfluid jet produced by a device that was designed to excite individual cochlear hair cell bundles or cupulae of the fish superficial lateral line system. The calibration involves a precise definition of the linearity and time- and frequency-dependent characteristics of the fluid jet as produced by a pressurized fluid-filled container combined with a glass pipette having a microscopically sized tip acting as an orifice.

Insights into the pore of the hair cell transducer channel from experiments with permeant blockers.

This chapter presents recent experiments designed to infer the properties of the ion-conducting pore of the mechanoelectrical transducer channel of sensory hair cells using permeant blockers. By combining results from experiments with three classes of large cationic permeant blockers, the fluorescent dye FM1-43, the aminoglycoside antibiotics, and the potassium-sparing diuretic amiloride, information has been obtained on the free energy profile along the transducer channel's pore as sensed by these blocker molecules. These energy profiles provide information about the position of the negatively charged binding site for the blockers as well as about positively charged barriers near the extracellular and intracellular faces of the channel that impede the blockers' permeation.

Source location encoding in the fish lateral line canal.

The position of a hydrodynamic dipole source, as encoded in a linear array of mechano-detecting neuromasts in the fish lateral line canal, was electrophysiologically investigated. Measured excitation patterns along the lateral line were compared to theoretical predictions and were found to be in good agreement. The results demonstrate that information on the position of a vibrating source from a fish is linearly coded in the spatial characteristics of the excitation pattern of pressure gradients distributed along the lateral line canal.

Hydrodynamic detection by cupulae in a lateral line canal: functional relations between physics and physiology.

In the present review, signal-processing capabilities of the canal lateral line organ imposed by its peripheral architecture are quantified in terms of a limited set of measurable physical parameters. It is demonstrated that cupulae in the lateral line canal organ can only partly be described as canal fluid velocity detectors. Deviation from velocity detection may result from resonance, and can be characterized by the extent to which a single dimensionless resonance number, N ( r ), exceeds 1.

The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels.

The most serious side-effect of the widely used aminoglycoside antibiotics is irreversible intracellular damage to the auditory and vestibular hair cells of the inner ear. The mechanism of entry into the hair cells has not been unequivocally resolved. Here we report that extracellular dihydrostreptomycin not only blocks the mechano-electrical transducer channels of mouse outer hair cells at negative membrane potentials, as previously shown, but also enters the cells through these channels, which are located in the cells' mechanosensory hair bundles.

Rapid responses of the cupula in the lateral line of ruffe (Gymnocephalus cernuus).

Displacements of cupulae in the supraorbital lateral line canal in ruffe (Gymnocephalus cernuus) have been measured using laser interferometry and by applying transient as well as sinusoidal fluid stimuli in the lateral line canal. The cupular displacement in response to impulses of fluid velocity shows damped oscillations at approximately 120 Hz and a relaxation time-constant of 4.4 ms, commensurate with a quality factor of approximately 1.

Channel gating forces govern accuracy of mechano-electrical transduction in hair cells.

Sensory hair cells are known for the exquisite displacement sensitivity with which they detect the sound-evoked vibrations in the inner ear. In this article, we determine a stochastically imposed fundamental lower bound on a hair cell's sensitivity to detect mechanically coded information arriving at its hair bundle. Based on measurements of transducer current and its noise in outer hair cells and the application of estimation theory, we show that a hair cell's transducer current carries information that allows the detection of vibrational amplitudes with an accuracy on the order of nanometers.