[A root canal treatment that has proved to be ineffective: considerations, possibilities and choices].

If a root canal treatment has proved to be ineffective, different treatment options are possible. It starts, however, with the discussion whether the tooth can or should be saved. Many considerations play a role in this choice: the clinical and radiographic findings, the professional's ideas, the patient, the scientific insights that alter the value of various factors during evaluation and the availability of a good alternative treatment.

Improvements in Resilience, Stress, and Somatic Symptoms Following Online Resilience Training: A Dose-Response Effect.

Objective: To determine if participation in an online resilience program impacts resilience, stress, and somatic symptoms.

Methods: Approximately 600 enrollees in the meQuilibrium resilience program received a series of brief, individually prescribed video, and text training modules in a user-friendly format. Regression models tested how time in the program affected change in resilience from baseline and how changes in resilience affected change in stress and reported symptoms.

Muscle 3243A-->G mutation load and capacity of the mitochondrial energy-generating system.

Objective: The mitochondrial energy-generating system (MEGS) encompasses the mitochondrial enzymatic reactions from oxidation of pyruvate to the export of adenosine triphosphate. It is investigated in intact muscle mitochondria by measuring the pyruvate oxidation and adenosine triphosphate production rates, which we refer to as the "MEGS capacity." Currently, little is known about MEGS pathology in patients with mutations in the mitochondrial DNA.

The mitochondrial 13513G > A mutation is most frequent in Leigh syndrome combined with reduced complex I activity, optic atrophy and/or Wolff-Parkinson-White.

The m.13513G > A transition in the mitochondrial gene encoding the ND5 subunit of respiratory chain complex I, can cause mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) and has been reported to be a frequent cause of Leigh syndrome (LS). We determined the frequency of the mutation in a cohort of 123 patients with reduced complex I activity in muscle (n = 113) or fibroblast (n = 10) tissue.

[A non-healing dark area: surgical treatment or non-surgical retreatment?].

There are a lot of studies discussing success rates of root canal treatment. They show a big variety in their outcomes. Success rates are reported between 54 and 96 percent with a majority reporting a figure towards the higher end of the range.

[Research methods in dentistry 4. Methods for evaluating the sealing ability of filling materials in the root canal].

In the past many in vitro studies were presented on the efficiency of the apical closure of the root canal. Such studies are relatively easy to perform in contrast to clinical studies. In order to determine which type of apical seal will give the best result, many techniques are evaluated.

Exercise intolerance, muscle pain and lactic acidaemia associated with a 7497G>A mutation in the tRNASer(UCN) gene.

A 13-year-old girl with non-familial exercise intolerance, muscle pain and lactic acidaemia underwent a muscle biopsy for suspected mitochondrial disease. Muscle morphology showed 25% ragged-red fibres and 80% COX-negative staining. Enzymatic activities of mitochondrially co-encoded respiratory chain enzymes (complexes I, III, and IV) were decreased in muscle but normal in cultured skin fibroblasts.

Monitoring pulp vitality after transplantation of teeth with mature roots: a case report.

Aim: To initiate discussion on the value of routine root canal treatment for transplanted teeth.

Summary: Autotransplantation is an accepted treatment option to replace missing teeth. It is generally considered that revascularization of the pulp following such a procedure is more favourable in teeth with immature roots.

[Formaldehyde in dental materials].

The use of formaldehyde in dentistry has been discussed for years. This because of the possible systemic effects of its use. This paper addresses the possible systemic effects of the use of formaldehyde and the question in which dental products formaldehyde is a component.

[Intracanal medication used in general dentistry].

In order to investigate the use of intracanal substances during root canal treatment 400 dentists were asked to take part in a questionnaire survey. Questions related to the substances used, the reason for use and the way they were used. Studied were the possible influences by the variables 'year of graduation', 'number of patients in practice', 'dental school'.

Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors.

It has been suggested that ovarian granulosa cell tumors may result from unopposed hyperstimulation, either by excessive gonadotropin stimulation, by activating mutations of the FSH receptor gene, or of the G protein subunits, Gs alpha or Gi alpha2. We have examined the entire open reading frame of the FSH receptor gene in ovarian granulosa cell tumors. In addition, these tumors were evaluated for the known oncogenic G protein mutations Gsp and Gip2.

Screening male intracytoplasmic sperm injection candidates for mutations of the follicle stimulating hormone receptor gene.

Follicle stimulating hormone (FSH) is considered to be essential for spermatogenesis. Therefore, genetic abnormalities of FSH signalling on testicular Sertoli cells would be expected to affect sperm production negatively in males. Inactivating FSH receptor mutations have been reported earlier in both males and females.