Publications by authors named "Sierra Barber"
Article Synopsis
- A study looked at how a special treatment method called the CREVICE protocol helped patients with severe brain injuries do better after 6 months compared to not using a protocol at all.
- They found that using CREVICE led to fewer deaths and better recovery scores for patients.
- The research involved 501 patients mostly from public hospitals in South America and showed that having a structured protocol made a positive difference in their care.
Background: Most patients with severe traumatic brain injury (sTBI) in low- or-middle-income countries and surprisingly many in high-income countries are managed without intracranial pressure (ICP) monitoring. The impact of the first published protocol (Imaging and Clinical Examination [ICE] protocol) is untested against nonprotocol management.
Objective: To determine whether patients treated in intensive care units (ICUs) using the ICE protocol have lower mortality and better neurobehavioral functioning than those treated in ICUs using no protocol.
Article Synopsis
- Intracranial pressure (ICP) monitoring for severe traumatic brain injury (sTBI) varies worldwide due to differences in resources and medical philosophies, with a lack of comprehensive management strategies for suspected intracranial hypertension (SICH) when monitoring is absent.
- A consensus conference with 43 Latin American medical professionals refined the existing BEST:TRIP algorithm, creating the CREVICE (Consensus REVised ICE) algorithm to define SICH and outline management and treatment options.
- The CREVICE algorithm serves as a structured decision-support model for sTBI management in settings without ICP monitoring, aiming to improve clinical care and guide future research, while being based on expert consensus due to limited existing literature.
Background: Without an effective vaccine, as was the case early in the 2014-2016 Ebola Outbreak in West Africa, disease control depends entirely on interrupting transmission through early disease detection and prompt patient isolation. Lateral Flow Immunoassays (LFI) are a potential supplement to centralized reference laboratory testing for the early diagnosis of Ebola Virus Disease (EVD). The goal of this study was to assess the performance of commercially available simple and rapid antigen detection LFIs, submitted for review to the WHO via the Emergency Use Assessment and Listing procedure.
View Article and Find Full Text PDFBackground: Traumatic brain injury (TBI) disproportionately affects lower- and middle-income countries (LMIC). The factors influencing outcomes in LMIC have not been examined as rigorously as in higher-income countries.
Methods: This study was conducted to examine clinical and demographic factors influencing TBI outcomes in Latin American LMIC.
Article Synopsis
- The ICE algorithm is a unique method for treating traumatic brain injuries without using a specialized device for measuring intracranial pressure (ICP).
- In a study involving 167 patients, the outcomes of those treated with the ICE method were similar to those who received standard monitored treatment, with a significant number surviving and showing improvement after 6 months.
- Although the ICE protocol had a low rate of problems during treatment, its effectiveness might not be the same in other places due to different medical practices and conditions, so more research is needed.
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Lancet
September 2014
Background: The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration.
Methods: To estimate incidence and mortality for HIV, we used the UNAIDS Spectrum model appropriately modified based on a systematic review of available studies of mortality with and without antiretroviral therapy (ART).