Identification of the c.829_832delAATA Deletion Variants in the Gene Associated with Hereditary Breast/Ovarian Cancer - Case Report.

Determination of the mutation status in patients with breast and/or ovarian cancer is commonly performed using various molecular techniques. The use of targeted PCR-based tests only may not be sufficient, as not all possible variants are investigated. In the present study, we used next-generation sequencing (NGS) techniques to identify novel pathogenic variants in and .

HER2 gene assessment in liquid biopsy of gastric and esophagogastric junction cancer patients qualified for surgery.

Background: Amplification of HER2 gene (ERBB2) and overexpression of HER2 protein on cancer cells are found in 10-26% of gastric cancer (GC) and esophagogastric junction cancer (EGJC). Gene copy number variation (CNV) could be detected in these patients in liquid biopsy and in cancer cells.

Methods: We analysed HER2 gene CNV used qPCR method in 87 sera collected from GC and EGJC patients before surgical treatment and in 40 sera obtained from healthy donors.

Perfusion CT - A novel quantitative and qualitative imaging biomarker in gastric cancer.

Objectives: The aim of this research was to examine whether Perfusion Computed Tomography (P-CT) can qualitatively and quantitatively help detect gastric cancer neoangiogenesis in vivo as well as treatment response evaluation. We attempted to explore which P-CT parameters are best used in neoangiogenesis and neoadjuvant therapy for most effective evaluation. We also tried to recognize a positive prediction value of P-CT in early responders and non-responders patients identification.

Cat scratch disease in 9-year-old patient - a case report.

Cat scratch disease (CSD) - bartonellosis, is zoonosis caused by the intracellular gram negativebacterium Bartonellahenselae or Bartonellaquintana. The pathogens of this disease enter the human body usually as a consequence of a bite or scratch by young cats which are the natural source of such bacteria. The illness proceeds asymptomatically or with topical symptoms of infection such as a lump, spot or blister.

Microsatellite polymorphism in the P1 promoter region of the IGF‑1 gene is associated with endometrial cancer.

Endometrial carcinoma (EC) is the most common type of gynecological malignancy. Studies have demonstrated that the insulin growth factor (IGF) pathway is implicated in the development of endometrial tumors and that the serum levels of IGF‑1 are affected by estrogen. Most EC cells with high microsatellite instability (MSI‑H) accumulate mutations at a microsatellite sequence in the IGF‑1 gene.

Effect of iodothyronine hormone status on doxorubicin related cardiotoxicity.

The anthracycline anticancer agent doxorubicin has been recognised to induce a dose-dependent cardiotoxicity. The chronic form of such complication is characterized by an irreversible cardiac damage and congestive heart failure. Although the pathogenesis of anthracycline cardiotoxicity seems to be multifactorial, the pivotal role has been attributed to reactive oxygen species formation.

The influence of a thyroxine supplemented diet on selected hepatic redox equilibrium markers, liver morphology and the serum lipid profile in rats treated with doxorubicin.

Introduction: Cytotoxicity of doxorubicin (DOX) - an anticancer drug, mostly results from reactive oxygen species (ROS) generation. Some enzymes catalyzing this process and enzymes of antioxidant defense are regulated by iodothyronine hormones. Thus, disorders in iodothyronine hormone status may affect doxorubicin-induced redox imbalance and anabolic/catabolic disorders.

Ovarian endometrioma in an 11-year-old girl before menarche: a case study with literature review.

Background: To date, a limited number of endometriosis cases occurring before or around the time of menarche have been documented.

Case: An 11-year-old adolescent underwent an emergency operation for left ovarian endometrioma. Her menarche occurred spontaneously 6 months after surgery.

Interaction of lymphocytes and thyrocytes in Graves' disease and nonautoimmune thyroid diseases in immunohistochemical and ultrastructural investigations.

Background: Graves' disease is the archetype for organ-specific autoimmune disorders. It is very important for our understanding of the mechanisms responsible for progression of autoimmunity. The aim of this study was to present interactions of lymphocytes and thyrocytes in the thyroid tissue in Graves' disease and nonautoimmune thyroid diseases.

Clinical and morphological analysis of 143 cases of "pulmonary peripheral shades" in patients treated in the department of thoracic surgery of Medical Academy in Lublin.

In spite of a constant development of various diagnostic methods, in many cases of "peripheral shades" the exploratory opening of the chest appears to be the only way leading to a correct diagnosis. In this study, 143 patients were examined. These patients were referred to the Thoracic Surgery Department because of peripheral shades in the lung areas observed, often accidentally; on regular checkup X rays.

Pulmonary lymphangioleiomyomatosis--a case report.

Lymphangioleiomyomatosis is a rare disease entity. A case of a 51-year-old man treated for respiratory insufficiency has been reported. Due to disseminated lesions in the pulmonary tissue the patient was assessed for the presence of sarcoidosis.