Publications by authors named "Sienna Rocha"
Article Synopsis
- Mitochondrial DNA (mtDNA) plays a crucial role in energy production and acts as a damage-associated molecular pattern (DAMP), which triggers immune responses and contributes to inflammation during various diseases.
- When cells experience mtDNA stress, such as during herpes simplex virus-1 infection, changes occur in mitochondrial structure and function, leading to the release of mtDNA into the cytoplasm and activation of the cGAS-STING immune pathway.
- The study suggests that mtDNA undergoing replication stress is selectively removed through a quality control mechanism involving endosomes, and this process could be a potential target for therapies aimed at reducing mtDNA-related inflammation during infections.
Unlabelled: Gastric cancer is a leading cause of cancer mortality and health disparities in Latinos. We evaluated gastric intratumoral heterogeneity using multiregional sequencing of >700 cancer genes in 115 tumor biopsies from 32 patients, 29 who were Latinos. Analyses focused on comparisons with The Cancer Genome Atlas (TCGA) and on mutation clonality, druggability, and signatures.
View Article and Find Full Text PDFBackground: Cancer is the leading cause of death among Latinos, the largest minority population in the United States (US). To address cancer challenges experienced by Latinos, we conducted a catchment area population assessment (CAPA) using validated questions from the National Cancer Institute (NCI) population health assessment supplement at our NCI-designated cancer center in California.
Methods: A mixed-methods CAPA was administered by bilingual-bicultural staff, with a focus on understanding the differences between foreign-born and US-born Latinos.