Publications by authors named "Sienna L Wu"
Article Synopsis
- Estrogens are important hormones for female reproductive health and influence immune responses, particularly during menopause.
- A study involved ovariectomized mice (removal of ovaries for estrogen loss) that were given hormone replacement and then subjected to an immune challenge to assess behavioral changes.
- Findings showed that estrogen loss led to altered social and affective behaviors in mice, indicating a connection between declining estrogen levels, microglial sensitivity in the brain, and increased vulnerability to negative emotional effects.
Aging and reduced exposure to environmental microbes can both potentiate neuroinflammatory responses. Prior studies indicate that immunization with the immunoregulatory and anti-inflammatory bacterium, Mycobacterium vaccae (M. vaccae), in aged rats limits neuroimmune activation and cognitive impairments.
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