Allogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness, Safety, Survival in the Wound Site, and Proteomic Impact.

Although encouraging results of adipose-derived stem cell (ADSC) use in wound healing are available, the mechanism of action has been studied mainly in vitro and in animals. This work aimed to examine the safety and efficacy of allogenic ADSCs in human diabetic foot ulcer treatment, in combination with the analyses of the wound. Equal groups of 23 participants each received fibrin gel with ADSCs or fibrin gel alone.

Long-Term Effects of Pedicle Clamping during Major Hepatectomy for Colorectal Liver Metastases.

The use of the Pringle maneuver (PM) varies widely among surgical departments. Its use depends on the operator and type of liver resection. The aim of this study was to determine the impact of the PM on patient outcomes when undergoing major liver resections.

The influence of oxygen deprivation and donor age on the effect of statins on human mesenchymal stromal cells.

To date, no study evaluated the effect of oxygen deprivation together with statins pretreatment on human mesenchymal stromal cells (MSCs). The aim of our study was to establish the influence of atorvastatin and rosuvastatin on MSC proliferation and cytotoxicity in different oxygenic conditions. Human MSCs isolated from the bone marrow (n = 12) were incubated with statins.

Venous thromboembolism after penetrating femoral and popliteal artery injuries: an opportunity for increased prevention.

Background: Trauma patients with penetrating vascular injuries have a higher rate of venous thromboembolism (VTE). The objective of this study was to determine the risk of VTE formation in penetrating femoral and popliteal vascular injuries and the effects of endovascular management of these injuries.

Methods: A retrospective study of Pennsylvania Trauma Outcome Study registry was conducted during a 5-year period (2013-2017).

Association of Early-Life Social and Digital Media Experiences With Development of Autism Spectrum Disorder-Like Symptoms.

Importance: Despite growing evidence that parent-child interactions and time viewing digital media affect child development, these factors have rarely been studied in association with autism spectrum disorder (ASD) symptoms.

Objective: To determine the association of experiential factors, including social activities and screen viewing in the first 18 months of life, perinatal factors, and demographic factors, with ASD-like symptoms and risk on the Modified Checklist for Autism in Toddlers (M-CHAT) at 2 years.

Design, Setting, And Participants: Data for this cohort study were derived from the National Children's Study, a US multicenter epidemiological study of environmental influences on child health and development.

Plasma microRNA-126-3p and neutrophil-to-lymphocyte ratio in patients with chronic kidney disease: relationships to ambulatory 24-h blood pressure.

Pro-inflammatory milieu of chronic kidney disease (CKD) results in endothelial damage and contributes to increased cardiovascular risk. The aim of the study was to evaluate association between neutrophil-to-lymphocyte ratio (NLR) and plasma relative expression of endothelially abundant miR-126-3p with circadian blood pressure (BP) pattern in CKD patients. This single-center observational study involved CKD stage 1-5 patients and healthy age- and sex-matched control subjects.

Treatment Facility Volume and Survival in Patients with Advanced Prostate Cancer.

Background: Despite improvements in medical management of advanced prostate cancer (aPC), it continues to be a leading cause of cancer death in men. Contemporary management of men with aPC is complex and requires resources to be more readily available at high-volume facilities.

Objective: To determine the relationship between facility volume and survival in men with aPC.

Lack of Growth of Small (≤2 mm Feeding Artery) Untreated Pulmonary Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia.

Purpose: To assess pulmonary arteriovenous malformation (PAVM) growth among patients with untreated PAVMs using imaging from long-term follow-up per hereditary hemorrhagic telangiectasia international guidelines.

Materials And Methods: Analysis included 88 untreated PAVMs from 21 patients (6 male;15 female; mean age at presentation 47 y; range, 12-68 y). Two CT studies with the longest interval between were evaluated (mean 8.

CXCL12 in Patients with Chronic Kidney Disease and Healthy Controls: Relationships to Ambulatory 24-Hour Blood Pressure and Echocardiographic Measures.

Background/aims: Chronic kidney disease is a pro-inflammatory condition where the interplay between different regulatory pathways and immune cells mediates an unfavorable remodeling of the vascular wall and myocardial hypertrophy. These mechanisms include the action of CXCL12. The aim of this study is to evaluate the association between serum CXCL12 with left ventricular hypertrophy (LVH) and blood pressure control in chronic kidney disease (CKD) patients.

Dracunculiasis Eradication: Are We There Yet?

This report summarizes the status of the global Dracunculiasis Eradication Program as of the end of 2017. Dracunculiasis (guinea worm disease) has been eliminated from 19 of 21 countries where it was endemic in 1986, when an estimated 3.5 million cases occurred worldwide.

Salivary testosterone may not serve as a screening test in the diagnosis of biochemical hyperandrogenism.

Aim: The diagnosis of biochemical hyperandrogenism is still challenging because a set of appropriate, recommended diagnostic tests has not been established. In our study, we aimed to answer the question of whether salivary testosterone is a reliable test to establish the diagnosis of biochemical hyperandrogenism as compared to serum total testosterone (TT) measured either by liquid chromatography-tandem mass spectrometry (LC-MS/MS) or immunoassay and to assess which set of biochemical tests would be the most appropriate for the identification of biochemical hyperandrogenism.

Methods: A total of 39 women, aged 18-45 years, with clinical or biochemical hyperandrogenism and 41 healthy individuals, aged 19-45 years, were enrolled in the study.

Factors Associated With Medical School Entrants' Interest in Military Financial Assistance in Exchange for a Service Obligation: The Michigan State University College of Human Medicine Cohort.

Introduction: The U.S. military offers comprehensive scholarships to medical students to help offset costs in exchange for either reserve or active duty service commitments.

The Octyltrimethylamonium Bromide Adsorption at the Mercury Electrode/NaClO4 Solution Interface.

The behaviour of octyltrimethylammonium bromide electrosorption on the mercury electrode in 1 mol/L NaClO4 was determined by means of double layer differential capacity measurements. The adsorption constants were derived from surface pressure data as a function of electrode charge density and cationic surfactant bulk concentration. Adsorption of octyltrimethylammonium bromide was analyzed using constants obtained from Frumkin, corrected Flory-Huggins and virial isotherms.

Adsorption of anionic surfactant at the electrode-NaClO solution interface.

Abstract: Adsorption of 1-decanesulfonic acid at the electrode-NaClO solution interface was determined by double-layer differential capacity measurements. At potentials less than -1,200 mV, the adsorption of the anionic surfactant on the electrode does not occur. Low concentrations of the anionic surfactant (below cmc) causes slight changes in the zero charge potential, , and the surface tension at this potential, .

Seasonal influenza and Tdap vaccination policies in Michigan hospitals: progress yet substantial capacity to improve.

We determined the prevalence of mandatory influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination policies for staff in Michigan hospitals and factors affecting policy implementation. Forty-one percent of responders reported a mandatory influenza vaccination policy, and 11% reported a mandatory Tdap vaccination policy. The support of hospital leadership is critical to policy implementation and overcoming barriers.

The Adsorption of Tetramethylthiourea at the Interface Electrode - NaClO4 in the Presence of Sodium 1-decanesulfonate.

Mixed adsorption layers properties made by two organic substances in which 1-decanesulfonic acid sodium salt undergoes physical adsorption and tetramethylthoiurea (TMTU) chemical adsorption in 1M NaClO4 on the mercury electrode are described. Based on differential capacity data - potential curves obtained at mercury electrode the double layers TMTU adsorption parameters were calculated whereas the adsorption constants were derived from pressure data as a function of electrode charge density and TMTU's bulk concentration. The interaction parameters point to weak repulsive interaction between the adsorbed TMTU molecules.

Mixed adsorption layers of 0.1 M tert-butanol-tetramethylthiourea at the interface of Hg/aqueous perchlorate solutions.

The electrosorption behavior of tetramethylthiourea (TMTU) on a mercury electrode from 1.0, 0.5, and 0.

Predictors of vaccination rates during a mass meningococcal vaccination program on a college campus.

Factors contributing to students' compliance with mass vaccination programs during meningococcal outbreaks have not been well described. A 1997 mass vaccination campaign at Michigan State University provided an opportunity to study such factors. Of 34,024 students in the target population, 17,538 (51.

[Nitrosamines].

The paper reviews data on the property and mechanism of toxicologic effects of nitrosamines. Particular attention is turned to metabolism and carcinogenesis of these compounds in view of their concentration in human environment.

The history and the effect of the mammography quality assurance legislation in Michigan.

This paper describes the history of mammography quality assurance legislation in Michigan, the first of its kind in the nation. It discusses the collaboration of multiple organizations in the legislative process as well as in the implementation of it. It describes the effect of the legislation on the quality of mammography throughout the state and summarizes the lessons learned from the process, especially as they apply to the implementation of the Mammography Quality Standards Act at the national level.

Mammography use and outcomes in a community. The Greater Lansing Area Mammography Study.

Background: Mammography is widely known to reduce morbidity and mortality from breast cancer, but a population-based assessment of mammography use and follow-up of mammography findings has not been reported previously.

Methods: An observational, population-based, follow-up study was conducted of all women having mammograms in the Greater Lansing, Michigan, metropolitan area, between June 1987 and June 1988. A total of 17,811 Greater Lansing women participated.

Clostridium perfringens outbreak associated with minestrone soup.

Clostridium perfringens food poisoning usually occurs after animal protein foods such as meat or poultry are consumed. In November 1990, an outbreak of gastrointestinal illness occurred among attendees at a conference of cake decorators held in Michigan. All 42 conference attendees were surveyed.