Publications by authors named "Sien-Yei Liew"
Enterovirus 71 (EV71) is the major causative agent in hand, foot, and mouth disease (HFMD), and it mainly infects children worldwide. Despite the risk, there is no effective vaccine available for this disease. Hence, a recombinant protein construct of truncated nucleocapsid protein viral protein 1 (NPt-VP1), which is capable of inducing neutralizing antibody against EV71, was evaluated in a mouse model.
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- Microenvironmental conditions significantly influence how cancer cells respond to plant extracts, especially in hypoxic environments where these cells often resist conventional therapies.
- A range of Traditional Chinese Medicine plant extracts were tested on human osteosarcoma cells to evaluate their cytotoxic effects during low oxygen (hypoxic) conditions compared to normal oxygen levels (normoxia).
- Results showed varied cytotoxic responses, with some extracts becoming more potent in hypoxia, while others' effectiveness decreased, highlighting the need for further investigation into plant extracts for targeting hypoxic cancer cells.