Tile-based Fisher ratio analysis of comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS) data using a null distribution approach.

Comprehensive two-dimensional (2D) gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) is a versatile instrumental platform capable of collecting highly informative, yet highly complex, chemical data for a variety of samples. Fisher-ratio (F-ratio) analysis applied to the supervised comparison of sample classes algorithmically reduces complex GC × GC-TOFMS data sets to find class distinguishing chemical features. F-ratio analysis, using a tile-based algorithm, significantly reduces the adverse effects of chromatographic misalignment and spurious covariance of the detected signal, enhancing the discovery of true positives while simultaneously reducing the likelihood of detecting false positives.

Tile-based Fisher-ratio software for improved feature selection analysis of comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry data.

Comprehensive two-dimensional (2D) gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) is a highly capable instrumental platform that produces complex and information-rich multi-dimensional chemical data. The data can be initially overwhelming, especially when many samples (of various sample classes) are analyzed with multiple injections for each sample. Thus, the data must be analyzed in such a way as to extract the most meaningful information.

Experimental study of the quantitative precision for valve-based comprehensive two-dimensional gas chromatography.

For complex sample analysis, there is a need for multidimensional chromatographic instrumentation to be able to separate more compounds, often in shorter time frames. This has led to the development of comprehensive two-dimensional chromatographic instrumentation, such as comprehensive two-dimensional gas chromatography (GC × GC). Lately, much of the focus in this field has been on decreasing peak widths and, therefore, increasing peak capacity and peak capacity production.

Achieving high peak capacity production for gas chromatography and comprehensive two-dimensional gas chromatography by minimizing off-column peak broadening.

By taking into consideration band broadening theory and using those results to select experimental conditions, and also by reducing the injection pulse width, peak capacity production (i.e., peak capacity per separation time) is substantially improved for one dimensional (1D-GC) and comprehensive two dimensional (GC×GC) gas chromatography.

Increasing selectivity in comprehensive three-dimensional gas chromatography via an ionic liquid stationary phase column in one dimension.

Recent advances in improving the selectivity and performance for a comprehensive, three-dimensional (3D) gas chromatograph (GC(3)) instrument are described. With GC(3), two six-port diaphragm valves are utilized as the interfaces between three, in-series capillary columns housed in a standard GC instrument fitted with a high data acquisition rate flame ionization detector (FID). Modulation periods for sampling from one column to the next are set so that sufficient slices (i.

Comprehensive three-dimensional gas chromatography with parallel factor analysis.

Development of a comprehensive, three-dimensional gas chromatograph (GC3) instrument is described. The instrument utilizes two six-port diaphragm valves as the interfaces between three, in-series capillary columns housed in a standard Agilent 6890 gas chromatograph fitted with a high data acquisition rate flame ionization detector. The modulation periods for sampling column one by column two and column two by column three are set so that a minimum of three slices (more commonly four or five) are acquired by the subsequent dimension resulting in both comprehensive and quantitative data.

[Mechanical ventilation in an anesthetic circle system using the lowest tidal volume--studies of 3 anesthesia ventilators in a lung model and an animal experiment].

No anesthesia ventilator attached to a circle system is manufactured for use in neonates. However, a small bellows can be supplied for the following anesthesia ventilators: Spiromat NS 656 (NS), Ventilog 2 (V2) and AV1 (Draeger Co.) We investigated the minimal tidal volume delivered by each of the three ventilators.

Demonstration of 2n spermatids in carriers of the "sex reversed" factor in the mouse by Feulgen cytophotometry.

The "Sex Reversed" factor (SXY) leads to development of XX males. The condition is transmitted by XY-Sxr males. The testes of XY-Sxr carriers are characterized by patches of defective spermatogenesis with meiotic failure and appearance of extraordinary large spermatids.