Publications by authors named "Siegbert Faiss"

Endoscopic submucosal dissection (ESD) has become a standard treatment for early gastric cancer (EGC), often fulfilling guideline criteria (GC) or expanded criteria (EC). When lesions exceed the EC, surgical resection is recommended. However, a subgroup of these patients are not treated surgically.

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  • The review discusses primary benign mesenchymal tumors of the pancreas, which are very rare and often diagnosed only after surgery.
  • These tumors are usually identified through postoperative histology, leading to significant pancreatic surgery even for benign cases.
  • The summary includes limited findings from abdominal imaging and endoscopic ultrasound (EUS), with some case reports demonstrating modern ultrasound techniques used for diagnosis.
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  • The review discusses mesenchymal pancreatic tumors that have intermediate biological behavior and how they appear in imaging studies.
  • These tumors are rare, much like their benign and malignant counterparts, and are typically diagnosed after surgery through histology.
  • The text also briefly summarizes the limited information available on ultrasound and endoscopic ultrasound findings, including the use of contrast-enhanced techniques for these pancreatic lesions.
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  • - This review details rare malignant pancreatic lesions, particularly focusing on the imaging characteristics of uncommon epithelial tumors like solid pseudopapillary neoplasm and acinar cell carcinoma.
  • - It highlights how these tumors can be visualized using ultrasound, endoscopic ultrasound (EUS), and contrast-enhanced techniques.
  • - The overview emphasizes that pancreatic tumors are diverse, and not all are the common types like ductal adenocarcinoma or neuroendocrine tumors.
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Background: The European Society of Gastroenterology and Endoscopy recommends a primarily flexible endoscopic approach for the treatment of Zenker's diverticulum. Due to the rarity of the disorder, evidence for its effectiveness and safety comes mainly from small, retrospective, single-center studies.

Methods: In this retrospective, observational, multicenter cohort study, data from six German tertiary referral centers were analyzed.

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  • ERCP is a complex medical procedure that carries significant risks, including complications like pancreatitis and bleeding, making specialized training and a high volume of procedures essential for success.
  • The success rate of ERCPs is closely tied to the number of procedures performed annually, with studies suggesting that centers performing at least 200 ERCPs per year demonstrate better outcomes.
  • Emerging reforms in German hospitals emphasize the need for minimum procedure volumes in specialized centers, highlighting that high-quality ERCP requires not just frequency, but also the availability of comprehensive resources and support for managing complications.
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Background And Goals: The therapy of buried bumper syndrome (BBS) is difficult. The aim of this retrospective multicenter study was to analyze the treatment methods with focus on effectiveness and safety of endoscopic techniques.

Methods: The analysis of all therapies and a comparison of the papillotome technique (PT) and needle knife-based nonpapillotome technique (NPT) were performed.

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  • This review categorizes and discusses rare malignant mesenchymal tumors of the pancreas, emphasizing their imaging characteristics.
  • It highlights that these tumors may present differently than the more common pancreatic cancers, like ductal adenocarcinoma or neuroendocrine tumors.
  • The overview consolidates existing data to provide a clearer understanding of these less common pancreatic tumors.
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Background: Early Barrett cancer can be curatively treated by endoscopic resection. The choice of the resection technique, however-endoscopic mucosal resection (EMR) or submucosal dissection (ESD)-largely depends on the assumed infiltration depth as judged by the endoscopist. However, the accuracy of endoscopic diagnosis of the degree of cancer infiltration is not known.

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Background & Aims: Endoscopic mucosal resection (EMR) is standard therapy for nonpedunculated colorectal polyps ≥20 mm. It has been suggested recently that polyp resection without current (cold resection) may be superior to the standard technique using cutting/coagulation current (hot resection) by reducing adverse events (AEs), but evidence from a randomized trial is missing.

Methods: In this randomized controlled multicentric trial involving 19 centers, nonpedunculated colorectal polyps ≥20 mm were randomly assigned to cold or hot EMR.

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  • * It highlights the importance of correlating ultrasound results with pathological features for better differential diagnosis, especially in high-risk populations where point-of-care ultrasound can serve as an initial screening tool.
  • * The review cautions that while ultrasound can aid in sample collection for tuberculosis testing, a diagnosis of extrapulmonary tuberculosis cannot be confirmed solely through ultrasound, as many findings are non-specific.
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Background And Aims: Endoscopic resection is accepted as standard treatment for intramucosal esophageal adenocarcinoma (EAC) that is well or moderately differentiated. Poor differentiation (PD) is judged as a risk factor for lymph node metastasis (LNM), and surgery is recommended. However, the evidence for this recommendation is weak.

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  • The article discusses guidelines from the World Federation for Medicine and Biology (WFUMB) regarding contrast-enhanced ultrasound (CEUS) specifically related to very rare focal liver lesions (FLL).
  • It focuses on the ultrasound appearance of peliosis hepatis and porphyria cutanea tarda, highlighting how these conditions can often be diagnosed visually without needing a biopsy.
  • The goal is to enhance clinicians' understanding of the clinical presentation and imaging characteristics of these focal liver lesions to improve diagnostic accuracy.
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Introduction: Despite growing awareness of post-coronavirus disease 2019 (COVID-19) cholangiopathy as one of the most serious long-term gastrointestinal consequences of COVID-19, the endoscopic features of this disease are still poorly characterized. This study aimed to more precisely define its endoscopic features and to outline the role of endoscopic retrograde cholangiopancreatography (ERCP) in the management of this entity.

Methods: In this observational study, 46 patients with confirmed post-COVID-19 cholangiopathy were included.

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We report the case of a 32-year-old male patient who presented with episodic, self-limiting gastrointestinal bleeding events. After both esophagogastroduodenoscopy (EGD) and colonoscopy remained unremarkable, capsule endoscopy revealed an unexplained mucosal lesion that presented as an ulcerated process on spiral enteroscopy. Appropriate enteroscopic ink marking was followed by surgical partial resection of the distal ileum, with histopathology revealing evidence of an arteriovenous malformation (AVM).

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Gastroenterology has made crucial advances in diagnostic and interventional endoscopic procedures, opening up improvements in the treatment of many patients. Thus, organ-preserving treatments are increasingly being made possible, replacing more invasive organ resecting surgical procedures. At the same time, the degree of complexity and risks varies widely between different endoscopic procedures.

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Background: For an adequate educational strategy of ESD in non-Asian settings with prevalence-based indication it is essential to define adequate lesions, suitable for the beginner without on-site expert-supervision.

Aims: We analyzed possible predictors for outcome parameters of effectiveness and safety during the initial learning curve.

Methods: The first 120 ESDs of four operators (n = 480), performed between 2007 and 2020 in four tertiary hospitals, were enrolled.

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During the aging process, typical morphological changes occur in the pancreas, which leads to a specific "patchy lobular fibrosis in the elderly." The aging process in the pancreas is associated with changes in volume, dimensions, contour, and increasing intrapancreatic fat deposition. Typical changes are seen in ultrasonography, computed tomography, endosonography, and magnetic resonance imaging.

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As part of the aging process, fibrotic changes, fatty infiltration, and parenchymal atrophy develop in the pancreas. The pancreatic duct also becomes wider with age. This article provides an overview of the diameter of the pancreatic duct in different age groups and different examination methods.

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Liver cirrhosis is associated with regenerative nodules and an increased risk of developing hepatocellular carcinoma (HCC). However, other benign and malignant liver lesions may also occur. Differentiating the other lesions from HCC is important for further therapeutic decisions.

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Background: Iatrogenic colorectal perforation is a rare event with a relevant mortality and the need for surgical therapy in around ¾ of cases.

Methods: In this retrospective multicentric cohort study iatrogenic colorectal perforations from 2004 to 2021 were analyzed. Primary outcome parameters were incidence and clinical success of 1st line endoscopic treatment.

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