Strategies to Improve Racial and Ethnic Diversity in Breast Imaging Training and Beyond.

Diversity and inclusion in breast imaging can improve creativity and innovation, enrich the workplace environment, and enhance culturally appropriate care for an increasingly diverse patient population. Current estimates predict the racial and ethnic demographics of the United States population will change markedly by the year 2060, with increases in representation of the Black demographic projected to comprise 15% of the population (currently 13.3%) and the Hispanic/Latinx demographic projected to comprise 27.

Clinicopathological and radiological characterization of myofibroblastoma of breast: A single institutional case review.

Myofibroblastoma is a rare type of benign myofibroblastic neoplasm in the breast. It is clinically presented as a well-circumscribed mass, usually small in size (usually less than 4.0 cm), and can mostly be cured by local excision.

Fast MRI breast cancer screening - Ready for prime time.

Objective: The manuscript discusses landmark studies using abbreviated MRI for breast cancer screening. This includes abbreviated dynamic contrast enhanced MRI and diffusion weighted imaging. Our institutional experience with abbreviated MR protocol for breast cancer screening is also described.

Implementing Abbreviated MRI Screening Into a Breast Imaging Practice.

The purpose of this article is to describe steps for implementing abbreviated breast MRI into a breast imaging practice. Mammographic screening for breast cancer has been the standard of care. However, breast cancer remains a leading cause of death of women.

Lobular neoplasia diagnosed on breast Core biopsy: frequency of carcinoma on excision and implications for management.

The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with recommendations ranging from close clinical follow-up or surveillance to mandatory surgical excision in all cases. We report the findings at our institution, where virtually every core needle biopsy diagnosis of lobular neoplasia results in follow-up excision.

Radial scars diagnosed on breast core biopsy: Frequency of atypia and carcinoma on excision and implications for management.

Aims: The risk of finding carcinoma in excisions following a core needle biopsy diagnosis of radial scar is not well defined and clinical management is variable. The aim of this study is to determine the frequency of high-risk lesions, ductal carcinoma in situ, and invasive carcinoma in excisions following a core biopsy diagnosis of radial scar.

Methods And Results: Dedicated breast pathologists and radiologists correlated the histologic and radiologic findings and categorized radial scars as the target lesion or an incidental finding.

Epithelial barrier function in vivo is sustained despite gaps in epithelial layers.

Background & Aims: Epithelial cells of the small intestine migrate to the tip of the villus at which they are shed. It is not understood how the intestinal barrier is maintained during this high cell turnover. The aim of this study was to use high-resolution in vivo light microscopy to investigate the mechanism of epithelial shedding and the site of the permeability barrier during cell shedding.

Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress.

Redox-sensitive signaling factors regulate multiple cellular processes, including proliferation, cell cycle, and prosurvival signaling cascades, suggesting their potential as molecular targets for anticancer agents. It is logical to set constraints that a molecular target should meet at least one of the following criteria: (1) inhibition of prosurvival signaling pathways; (2) inhibition of cell cycle progression; or (3) enhancement of the cytotoxic effects of anticancer agents. Therefore, we hypothesized that thioredoxin reductase 1 (TR), a component of several redox-regulated pathways, might represent a potential molecular target candidate in response to agents that induce oxidative stress.

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

Ansamycin antibiotics inhibit function of the heat shock protein (HSP) 90, causing selective degradation of several intracellular proteins regulating such processes as proliferation, cell cycle regulation, and prosurvival signaling cascades. HSP90 has been identified previously as a molecular target for anticancer agents, including ionizing radiation (IR). Therefore, we hypothesized that the ansamycin geldanamycin and its 17-allylamino-17-demethoxy analog (17-AAG), which inhibit HSP90, would enhance tumor cell susceptibility to the cytotoxicity of IR.

A double-blind cross-over study of a non-linear hearing aid.

New hearing aids are usually introduced after clinical trials. These are mostly based on subjects reports, in which it is possible that the subject's judgment of the acoustic performance might be influenced by the awareness that it is a new hearing aid which is being investigated. To examine the benefit of a new non-linear amplification circuit, a double-blind cross-over study was conducted.

Protonated p-Benzoquinone.

The structure and energetics of protonated p-benzoquinone (pBQ) have been investigated using high-pressure mass spectrometry and ab initio calculations. The experimental proton affinity of pBQ is 801.4 +/- 8.

Photoionization of CO -CO-O Mixtures. Formation and Reactions of Ion Clusters.

Various mixtures containing combinations of CO, O, or CO have been photoionized at 16.7 and 21.2 eV at pressures up to 1.

Ion-Molecule Reactions in Isopropanol: Implications for Its Radiolysis.

The photoionization of isopropanol (-PrOH) at 11.7 eV has been investigated in the NBS high pressure photoionization mass spectrometer over the pressure range 0.1 to approximately 200 millitorr.

Photoionization of Propylene, Cyclopropane, and Ethylene. The Effect of Internal Energy on the Bimolecular Reactions of and .

The ion-molecule chemistry occurring in photoionized ethylene, propylene and cyclopropane has been investigated in the NBS high pressure mass spectrometer. Emphasis has been placed on determining the overall effect of internal excitation on the absolute rate coefficients for the various reactions. This was accomplished by comparing the behavior found when ionization was induced by photon absorption at the ionization threshold with that found at higher photon energies.

Photoionization of Isomers. Unimolecular and Bimolecular Reactions of the Ions.

1-Butene, -2-butene, isobutene and methylcyclopropane have been photoionized with the resonance lines of krypton (10.0-10.6 eV) and argon (11.

Kinetic Mass Spectrometric Investigation of the Reactions of Ions With Some Simple Polar Molecules at Thermal Energies.

The interactions of ions from neopentane with some simple polar molecules have been investigated in a high pressure photoionization mass spectrometer at thermal kinetic energies. Proton transfer was found to occur from to acetone, ammonia, and the various methylamines, but not to molecules having estimated proton affinities < 195 kcal/mol (815 kJ/mol). Macroscopic thermal rate coefficients are reported for the various proton transfer reactions, all of which are on the order of 10 cm/molecule · second.

Kinetic Mass Spectrometric Investigation of the Ion-Molecule Reactions Occurring in C and C Alkanes Following Photoionization at 106.7 and 104.8 nm.

The photoionization of C and C alkanes has been investigated at 106.7 and 104.8 nm in a mass spectrometer specifically designed for the investigation of ion-molecule reactions occurring at thermal kinetic energies.