Publications by authors named "Sieberth Do Nascimento Brito"
Article Synopsis
- The paper introduces a new method for analyzing viral genetic diversity using high-throughput sequencing, specifically focusing on viruses like HIV-1 and Influenza that have high nucleotide substitution rates.
- The proposed method utilizes short reads from various sequencing technologies, capitalizing on their low error rates and deep coverage, thereby bypassing the complications associated with longer reads and haplotype reconstruction.
- Results indicate that genetic diversity can be quantified using multinomial probability distributions for nucleic bases at each site within the viral genome, employing Bayesian techniques to refine estimates and distinguish between genuine data and noise.
In contrast to most gammaherpesviruses, Bovine herpesvirus 4 (BoHV-4) has a broad range of host species both in vitro and in vivo. Several in vitro studies demonstrated that some human cell lines are sensitive or even permissive to BoHV-4. These observations led to the hypothesis that cross-species transmission of BoHV-4 could lead to human infections.
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