Publications by authors named "Sidra Aurangzeb"
Article Synopsis
- New-onset refractory status epilepticus (NORSE) is a serious condition where the cause is unknown in 30%-50% of patients and treatment options are not standardized.
- A study of 48 patients who survived the initial phase revealed that many experienced high rates of ongoing epilepsy and significant cognitive, vocational, and mental health challenges after discharge.
- The findings highlight that the long-term outcomes for NORSE survivors are often devastating, underlining the urgent need for better understanding and targeted treatment methods.
Introduction: Literature on New-Onset Refractory Status Epilepticus (NORSE) is scarce and management is guided mainly by retrospective reports, short case series or expert opinions. We aimed to add to the pool of the available data by retrospectively reviewing seven cases of NORSE cases admitted to our hospital over the last five years between January 2014 and March 2019.
Methods: Fully anonymised data from medical charts, EEG reports, imaging reports, laboratory test results, types of antiepileptic medications, intravenous anaesthetic therapy, and immune therapies received was collected, along with response to treatment, length of hospital stay and outcome at discharge.
Status epilepticus is a common neurological emergency, with overall mortality around 20%. Over half of cases are first time presentations of seizures. The pathological process by which spontaneous seizures are generated arises from an imbalance in excitatory and inhibitory neuronal networks, which if unchecked, can result in alterations in intracellular signalling pathways and electrolyte shifts, which bring about changes in the blood brain barrier, neuronal cell death and eventually cerebral atrophy.
View Article and Find Full Text PDFPurpose: To describe clinical and electrographic characteristics of seizures LGI1-antibody encephalitis, and their correlations with two-year outcomes.
Methods: Video-electroencephalography recordings were performed on a cohort of 16 consecutive patients with LGI1-antibodies from two UK neuroscience-centers over five-years.
Results: From 14 of 16 patients (13 males; age-range 53-92years), 86 faciobrachial dystonic seizures were recorded at a median frequency of 0.
Objective: To study the relationship of anti acetylycholine receptor antibody (AchR-Ab) titres with the demographic profile and severity of myasthenia gravis (MG).
Methods: This prospective study was carried out on inpatients and outpatients at the Department of Neurology at Pakistan Institute of Medical Sciences, Islamabad. Seropositive cases of myasthenia gravis were collected and were classified as having low AchR-Ab titres (< 50 nmol/L) and high AchR-Ab titres (> 50 nmol/L).
Chest radiographic findings in neurotuberculosis without pulmonary signs and symptoms.
J Coll Physicians Surg Pak
January 2008
Objective: To determine the chest radiographic findings in patients of adult neurotuberculosis, with no pulmonary signs and symptoms.
Study Design: Descriptive study.
Place And Duration Of Study: Department of Neurology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan, from January 2004 to January 2006.
Objective: To evaluate the effectiveness of superoxidized water (MicrocynTM) in diabetic patients with different wounds.
Study Design: Single-centre single blinded randomized controlled trial.
Place And Duration Of Study: Department of General Surgery, Orthopaedics and General Medicine at Pakistan Institute of Medical Sciences, Islamabad, from April to June 2006.