Cribriform degeneration (cri): a new recessive neurological mutation in the mouse.

The mutation cribriform degeneration (cri) occurred in the DBA/2J strain; it is in linkage group VIII, 31 recombination units from b. Homozygotes show severe vacuolar degeneration in white and gray matter of the spinal cord and brainstem, normocytic anemia at birth which decreases in severity with age, and abnormalities of electrolyte distribution.

Photoreceptor-pigment epithelial cell relationships in rats with inherited retinal degeneration. Radioautographic and electron microscope evidence for a dual source of extra lamellar material.

Protein synthesis and displacement in photoreceptor and pigment epithelial cells of inbred normal (Fisher) and mutant (RCS) rats with inherited retinal degeneration has been studied by light and electron microscope radioautography. Groups of animals 14, 15, 17, 19, 27, 35, and 50 days of age were injected with amino acids-H(3) and killed at subsequent time intervals. In normal rats, radioactive protein synthesized in the rod inner segments was incorporated into outer segment saccules and displaced outward; the total renewal time of outer segments at all ages was approximately 9 days.

MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM.

Two mutant mice with deficient myelination are described. Quaking is a new autosomal recessive mutant mouse with marked tremor of the hindquarters. The mice eat, swim, breed, and nurse well even though the entire central nervous system is very deficient in myelin by histological and chemical criteria.