The scientist/practitioner in behavior analysis: A case study.

This article is a transcription of Murray Sidman's presentation at the annual meeting of the Society for the Quantitative Analysis of Behavior in May 1998. It describes the development (from 1965 to 1975) of behavior-change programs implemented outside the animal laboratory to benefit humans before such application was established formally as an entity derived from the experimental analysis of behavior. The presentation illustrates the use of an inductive method in practice, where working with a fluid behavior stream entails making intervention decisions on the spot.

Can an understanding of basic research facilitate the effectiveness of practitioners? Reflections and personal perspectives.

I have written before about the importance of applied behavior analysis to basic researchers. That relationship is, however, reciprocal; it is also critical for practitioners to understand and even to participate in basic research. Although applied problems are rarely the same as those investigated in the laboratory, practitioners who understand their basic research background are often able to place their particular problem in a more general context and thereby deal with it successfully.

Long-term efficacy and safety of laronidase in the treatment of mucopolysaccharidosis I.

Objective: Our goal was to evaluate the long-term safety and efficacy of recombinant human alpha-l-iduronidase (laronidase) in patients with mucopolysaccharidosis I.

Patients And Methods: All 45 patients who completed a 26-week, double-blind, placebo-controlled trial of laronidase were enrolled in a 3.5-year open-label extension study.

Equivalence relations and behavior: an introductory tutorial.

With an emphasis on procedural fundamentals, the original behavior-analytic equivalence experiments and the equivalence paradigm are described briefly. A few of the subsequent developments and implications are noted, with special reference to the possible significance of the findings with respect to language and cognition.

A dose-optimization trial of laronidase (Aldurazyme) in patients with mucopolysaccharidosis I.

Recombinant human alpha-l-iduronidase (Aldurazyme), laronidase) is approved as an enzyme replacement therapy to treat the lysosomal storage disorder, mucopolysaccharidosis type I (MPS I) at a dose of 0.58 mg/kg by once-weekly intravenous infusion. To assess whether alternate dosing regimens might provide a better reduction in lysosomal storage, a 26-week, randomized, open-label, multinational dose-optimization trial was conducted.

Reflections on stimulus control.

The topic of stimulus control is too broad and complex to be traceable here. It would probably take a two-semester course to cover just the highlights of that field's evolution. The more restricted topic of equivalence relations has itself become so broad that even an introductory summary requires more time than we have available.

The analysis of behavior: what's in it for us?

When we publish behavioral research, we are not allowed to communicate the thrill, the poetry, or the exhilaration that are outcomes of the discovery process. Yet, these are among our most potent reinforcers. Explicit recognition of the emotional accompaniments to research could help attract students into the experimental analysis of behavior.

Equivalence classes with requirements for short response latencies.

Five adult humans were tested for emergent conditional discriminations under rapid-responding contingencies. During four-comparison matching-to-sample baseline training (AB and AC), limited-hold contingencies for responding to samples and comparisons were gradually restricted to the shortest duration consistent with at least 95% accuracy and no more than 5% failures to respond. The final limited-hold values were 0.

The analysis of human behavior in context.

Does the name of the special interest group, "The Experimental Analysis of Human Behavior," imply that those who analyze the behavior of human animals must organize themselves apart from those who analyze the behavior of nonhuman animals? Is the use of nonhumans in experiments really not relevant to the analysis of the behavior of humans? If so, then something must have changed. Many differences exist, of course, between the behavior of humans and nonhumans-humans, for example, cannot fly under their own power-but have we really isolated differences in principle, differences that require separate organizations for the study of each? I will try to indicate why I believe this is a serious concern, where the concern comes from, and what, perhaps, might be done to maintain what was once a flourishing bidirectional relation between research with humans and nonhumans, in both basic and applied research.

Notes from the beginning of time.

Some remembrances of things past, and their possible relevance to things now. These remembrances include notes about informality, research as a social process, student training and evaluation, research grants, thesis and dissertation proposals, and interdisciplinary collaboration.

Equivalence relations and the reinforcement contingency.

Where do equivalence relations come from? One possible answer is that they arise directly from the reinforcement contingency. That is to say, a reinforcement contingency produces two types of outcome: (a) 2-, 3-, 4-, 5-, or n-term units of analysis that are known, respectively, as operant reinforcement, simple discrimination, conditional discrimination, second-order conditional discrimination, and so on; and (b) equivalence relations that consist of ordered pairs of all positive elements that participate in the contingency. This conception of the origin of equivalence relations leads to a number of new and verifiable ways of conceptualizing equivalence relations and, more generally, the stimulus control of operant behavior.

Visual identity matching and auditory-visual matching: a procedural note.

After preliminary computerized training on visual-visual identity matching, a 5-year-old boy with autism (Sam) was given visual-visual and auditory-visual matching-to-sample tests with new stimuli. He did well in matching dictated name samples to 20 pictures, 26 printed upper case letters, and 9 single-digit numbers. In matching the visual stimuli (pictures, letters, or numbers) to themselves, however, he did not perform well.

A note on transfer of stimulus control in the delayed-cue procedure: facilitation by an overt differential response.

This case study describes initially unsuccessful attempts to use the delayed-cue procedure to teach conditional discriminations to an individual with moderate mental retardation. The task was matching printed-word comparison stimuli to dictated-name sample stimuli. In three experiments, the subject typically waited for the delayed cue unless differential responses to the dictated samples (repeating the sample names) were required.

Conditional discrimination and equivalence relations: Control by negative stimuli.

Three adult subjects were taught the following two-sample, two-comparison conditional discriminations (each sample is shown with its positive and negative comparison, in that order): A1-B1B2, A2-B2B1; B1-C1C2, B2-C2C1; and C1-D1D2, C2-D2D1. A teaching procedure was designed to encourage control by negative comparisons. Subjects were then tested for emergent performances that would indicate whether the baseline conditional discriminations were reflexive, symmetric, and transitive.

Conditional discrimination and equivalence relations: A theoretical analysis of control by negative stimuli.

A detailed analysis is presented of the ways in which control by the negative stimulus in two-comparison conditional discriminations may be expected to affect the outcome of tests for the properties of equivalence relations. Control by the negative stimulus should produce the following results: (a) no observable effect on symmetry tests; (b) reflexivity test results should look like "oddity" rather than "identity"; and (c) transitivity tests that involve an odd number of nodes should yield results that are 100% opposite to tests that involve an even number of nodes. The analysis also considers the effects of variation in the type of comparison-stimulus control between and within baseline conditional discriminations.

Adventitious control by the location of comparison stimuli in conditional discriminations.

In a conditional discrimination procedure, samples appeared in a center key, and comparisons appeared in two of four outer keys. The location of comparison keys varied from trial to trial. Separate learning curves for each of the six possible pairs of comparison keys were plotted in a signal-detection space, revealing different patterns of progress on each pair.

An instance of spurious equivalence relations.

Four normal children learned conditional discriminations that had upper-case or lower-case Greek letters as comparison stimuli, and dictated letter names as samples. Experimental stimuli were three pairs of letters; within each pair, an upper- and a lower-case letter were conditionally related to the same dictated sample. Four control stimuli, also upper- and lower-case letters, were each conditionally related to a different dictated sample.

Functional classes and equivalence relations.

Three adult subjects were taught a set of two-choice simultaneous discriminations, with three positive and three negative stimuli; all possible combinations of positive and negative stimuli yielded nine different pairs. The discriminations were repeatedly reversed and rereversed, the former positive stimuli becoming negative and the former negative stimuli becoming positive. With all subjects, a reversal of the contingencies for one pair of stimuli became sufficient to change their responses to all of the other pairs.