Atypical Type 2 Lepra Reaction Masquerading as Recurrent Sweet Syndrome.

Erythema nodosum leprosum (ENL) is an immune complex-mediated response in Mycobacterium leprae infection, presenting with fever, arthralgias, and tender cutaneous lesions. It mimics Sweet syndrome (SS) clinically and histologically but requires distinct management. A 65-year-old man with recent travel presented with fever and edematous plaques.

Treatment of hidradenitis suppurativa with 755-nm alexandrite laser hair removal: A randomized controlled trial.

Background: Hidradenitis supprativa is a chronic inflammatory skin disease that can respond to treatment with laser hair removal.

Objective: To assess alexandrite laser hair removal laser as a treatment for hidradenitis suppurativa as measured by the Hidradenitis Supprativa Clinical Response.

Materials And Methods: We conducted a prospective, randomized, controlled study in adult patients with hidradenitis supprativa.

Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function.

Tauopathies are neurodegenerative disorders in which the pathological intracellular aggregation of the protein tau causes cognitive deficits. Additionally, clinical studies report muscle weakness in populations with tauopathy. However, whether neuronal pathological tau species confer muscle weakness, and whether skeletal muscle maintains contractile capacity in primary tauopathy remains unknown.

Preoperative Templating for Total Hip Arthroplasty: A Method for Calibrating Digital Radiographs Using Patient Demographics and Anthropometric Measurements.

Background Preoperative templating aids the surgeon in estimating implant size and placement. Calibration markers are used to set the correct magnification of digital images before templating. Improper marker placement or complete absence can lead to inaccuracy or an inability to calibrate images altogether.

Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function.

Tauopathies are neurodegenerative disorders in which the pathological intracellular aggregation of the protein tau causes cognitive deficits. Additionally, clinical studies report muscle weakness in populations with tauopathy. However, whether neuronal pathological tau species confer muscle weakness, and whether skeletal muscle maintains contractile capacity in primary tauopathy remains unknown.

Images indexing and matched assessment of semantics and visuals similarities applied to a medical learning X-ray image base.

Background: Medical diagnostic support systems are important tools in the field of radiology. However, the precision obtained, during the exploitation of high homogeneity image datasets, needs to be improved.

Objective: To develop a new learning system dedicated to public health practitioners.

Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice.

RNA binding protein motif 3 (RBM3) is an RNA-binding and cold shock protein that protects myoblasts and promotes skeletal muscle hypertrophy by enhancing mRNA stability and translation. Muscle size is decreased during aging; however, it is typically delayed in models of extended lifespan such as the long-lived Ames Dwarf (df/df) mice and calorie restricted (CR) animals compared to age-matched controls. In light of the protective and anabolic effects of RBM3 in muscle, we hypothesized that RBM3 expression is higher in long-lived animal models.

How Accurate is the Use of Contralateral Implant Size as a Template in Bilateral Hemiarthroplasty?

Purpose: Accurately predicting implant size for hemiarthroplasties offers an important contribution to theatre efficiency and patients' intraoperative care. However, pre-operative sizing using templating of implants in hip fracture patients requiring a hemiarthroplasty is often difficult due to non-standard radiographs, absence of a calibration marker, poor marker placement, variable patient position, and in many institutions a lack of templating facilities. In patients who have previously undergone a hemiarthroplasty on the contralateral side, surgeons can use the contralateral implant size for pre-operative planning purposes.

17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner.

Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of the most conserved biological pathways that regulates aging across species. 17α-Estradiol (17α-E2), a diastereomer of 17β-estradiol (17β-E2), was recently found to elicit health benefits, including improved insulin sensitivity and extend longevity exclusively in male mice.

17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.

Growth hormone receptor knockout mice (GHRKO) have reduced body size and increased insulin sensitivity. These mice are known for having extended lifespan, healthspan and female reproductive longevity. Seventeen α-estradiol (17α-E2) is reported to increase insulin sensitivity and extend lifespan in male mice, with less robust effects in female mice.

There is no 'weekend effect' in elective orthopaedic surgery.

Introduction The 'weekend effect' is said to occur when patient outcomes are adversely affected by the day of the week on which they present to hospital or have surgery. However, it is uncertain whether such a phenomenon exists for elective orthopaedic surgery. We investigated whether there is a 'weekend effect' in elective orthopaedic patients.

Are Albumin Levels a Good Predictor of Mortality in Elderly Patients with Neck of Femur Fractures?

Background: Neck of femur (NOF) fractures are associated with significant morbidity and mortality in elderly people with multiple co-morbidities; making management of this patient subgroup challenging. Predictors of an increase in morbidity and mortality would therefore provide a useful framework for the assessment and management of this demographic. Within the current literature, hypoalbuminaemia (<35g/dl) has been highlighted as being a good biochemical predictor of short-term mortality (<12 months).

Retrospective review of patients with atypical bisphosphonate related proximal femoral fractures.

Introduction: Patients may be at an increased risk of atypical proximal femoral fractures with prolonged bisphosphonate use.

Patients And Methods: This was a retrospective review of patients who sustained a subtrochanteric fracture of the femur in our department between April 2009 and March 2014. The radiographs were reviewed for features of atypical femoral fractures as described by the American Society of Bone Mineral Research.

Use and Outcomes of Noninvasive Ventilation for Acute Respiratory Failure in Different Age Groups.

Background: The prevalence of chronic disease and do-not-intubate status increases with age. Thus, we aimed to determine characteristics and outcomes associated with noninvasive ventilation (NIV) use for acute respiratory failure (ARF) in different age groups.

Methods: A database comprising prospective data collected on site on all adult patients with ARF requiring ventilatory support from 8 acute care hospitals in Massachusetts was used.

Where is Noninvasive Ventilation Actually Delivered for Acute Respiratory Failure?

Purpose: Few studies have examined locations of noninvasive ventilation (NIV) application for acute respiratory failure (ARF). We aimed to track actual locations of NIV delivery and related outcomes.

Methods: Observational cohort study based at 8 acute care hospitals in Massachusetts on adult patients admitted for ARF requiring ventilatory support during pre-determined time intervals.

Outcome of the Stryker® Trident 'All-Poly' constraint acetabular insert: a district general hospital experience.

Introduction: Constrained acetabular inserts are designed as revision solutions for unstable total hip arthroplasties to prevent dislocation and as a possible primary option for elderly patients at risk of recurrent dislocation.

Purpose: Our aim was to establish clinical and radiological outcomes of an 'all-poly' constrained acetabular device and to highlight reasons for component failure.

Methods: We retrospectively reviewed our use of the Stryker® Trident 'all-poly' constrained acetabular insert between 2008 and 2013.

Use and outcomes of noninvasive positive pressure ventilation in acute care hospitals in Massachusetts.

Background: This study determined actual utilization rates and outcomes of noninvasive positive pressure ventilation (NIV) at selected hospitals that had participated in a prior survey on NIV use.

Methods: This observational cohort study, based at eight acute care hospitals in Massachusetts, focused on all adult patients requiring ventilatory support for acute respiratory failure during predetermined time intervals.

Results: Of 548 ventilator starts, 337 (61.

Evaluation of the total face mask for noninvasive ventilation to treat acute respiratory failure.

Background: We hypothesized that the total face mask (TFM) would be perceived as more comfortable than a standard oronasal mask (ONM) by patients receiving noninvasive mechanical ventilation (NIV) therapy for acute respiratory failure (ARF) and would be quicker to apply by respiratory therapists.

Methods: Sixty patients presenting with ARF were randomized to receive NIV via either an ONM or a TFM. Mask comfort and dyspnea were assessed using visual analog scores.

Gender differences in distal femoral morphology and the role of gender specific implants in total knee replacement: a prospective clinical study.

Gender differences in distal femoral morphology may affect femoral component fit using a standard range of prostheses. The clinical relevance of this is controversial. Standardised measurements were taken from the distal femora of 50 males and 50 females during total knee replacement (TKR).

Case report: Rhodococcus erythropolis osteomyelitis in the toe.

The Rhodococcus species rarely cause musculoskeletal infections, with only two cases reported in the literature. We report the case of a 53-year-old woman who had an infection develop after first metatarsophalangeal joint fusion. A year after surgery, she continued to have pain and swelling with nonunion.

Long-term clinical review (10-20 years) after reconstruction of the anterior cruciate ligament using the Leeds-Keio synthetic ligament.

Prosthetic ligament use for anterior cruciate ligament (ACL) reconstruction was popular in the 1980s and 1990s. Information from published studies regarding the long-term outcomes of this surgery is limited. This paper presents the long-term results of stabilization of the ACL deficient knee using the Leeds-Keio synthetic ligament formed from woven polyester.

[In-hospital prognosis of right ventricular myocardial infarction].

Aim: To identify prognostic risk factors for in-hospital outcome of right ventricular myocardial infarction (RVI).

Methods: A retrospective study of 20 patients admitted with acute myocardial infarction with a RVI defined by ST segment elevation > or = 1 mm in V3R and V4R leads.

Results: The mean age was 62 years.

A minimally invasive surgical technique for augmented reconstruction of the lateral ankle ligaments with woven polyester tape.

Although stabilization of the lateral ankle ligament complex (LALC) with augmented techniques is known to be successful, it is associated with a number of complications. We hypothesize that successful stabilization of LALC can be achieved with a woven polyester tape implant via a minimally invasive procedure, as an alternative to tenodesis. Four men with chronic instability of the ankle underwent a minimally invasive surgical stabilization of LALC with a woven polyester tape.