Photochemical domino reaction driven C-H/S-H functionalization of bioactive molecules to access xanthene scaffolds.

A visible-light-induced C(sp)-H functionalization of indoles by using Schreiner's thiourea as the organocatalyst has been reported. With the aid of a three-component domino reaction between 2-hydroxybenzaldehydes, cyclic-1,3-diketones, and a variety of indoles, the corresponding densely functionalized xanthene scaffolds were isolated in good to excellent yields. Apart from these, a broad range of other bioactive natural products including kojic acid, lawsone, and 4-hydroxycoumarin were also investigated instead of indoles for the present work.