Publications by authors named "Sidharth Saini"
Background: Peritumoral edema on staging magnetic resonance imaging (MRI) is associated with higher local recurrence in soft tissue sarcoma (STS). This may relate to the presence of satellite malignant cells that are difficult to distinguish from benign atypia, leading to over- or undertreatment. This study evaluated a novel targeted molecular approach to identify malignancy in STS peritumoral planes as a means to improve personalized care.
View Article and Find Full Text PDFObjective: Computer-assisted three-dimensional navigation often guides spinal instrumentation. Optical topographic imaging (OTI) offers comparable accuracy and significantly faster registration relative to current navigation systems in open posterior thoracolumbar exposures. We validate the usefulness and accuracy of OTI in minimally invasive spinal approaches.
View Article and Find Full Text PDFDiagnostic dilemmas are ubiquitous in pediatric emergency medicine because of the varied and often insidious presentations of many pediatric conditions. Point-of-care ultrasound (POCUS) in emergency departments is being used for some of these diagnostic challenges and can often provide rapid and valuable information to supplement a physician's clinical assessment. Intussusception is a pediatric condition that may be challenging to recognize because of its subtle and varied presenting symptoms.
View Article and Find Full Text PDFArticle Synopsis
- The malaria parasite Plasmodium falciparum has unique adaptations that help it invade and reproduce in human red blood cells.
- A key structure called the inner membrane complex (IMC) plays a crucial role in this invasion process and contains numerous specialized proteins.
- The study identifies a specific palmitoyl acyltransferase enzyme (PfDHHC1) localized within the IMC, which is essential for understanding how certain proteins are recruited to this membrane structure during the parasite's life cycle.
Objective: To compare the degree of small bowel distension achieved by 3% sorbitol, a high osmolarity solution, and a psyllium-based bulk fibre as oral contrast agents (OCAs) in MR enterography (MRE).
Methods: This retrospective study was approved by our institutional review board. A total of 45 consecutive normal MRE examinations (sorbitol, n = 20; psyllium, n = 25) were reviewed.