Identifying Potential Autophagy Modulators in Panch Phoron Spices (P5S): An In Silico approach.

Despite recent breakthroughs in diagnosis and treatment, cancer remains a worldwide health challenge with high mortality. Autophagy plays a major role in the progression and development. Starving cancer cells obtain nutrients through the upregulation of autophagy.

Challenges in practice and training structure of residents in obstetric anaesthesia: A perspective from teaching hospitals in Sindh province of Pakistan.

Objectives: To document information on the available obstetric anaesthesia services and structure of resident training in a Pakistani setting.

Methods: The survey was conducted from June to September 2018 across the Sindh province of Pakitan after approval from the ethics reiew committee of the Pakistan Society of Anaesthesiology, and covered all teaching hospitals in both public and private sectors recognised for residents' training for fellowship in Anaesthesiology by the College of Physician and Surgeons of Pakistan. A standardised questionnaire was filled by either the department chairperson or a senior designated faculty member in each institution regarding obstetric anaesthesia services and structure of resident training.

What About Nights, Weekends, and Wait Times? Adding an On-Demand Facilitated Telemedicine Buprenorphine Component to a Community-Based Peer Support Outreach Program.

Background: In 2020, loosened federal regulations allowed for buprenorphine for opioid use disorder to be initiated via telemedicine. In response to these regulatory changes and growing racial inequities in overdose in St. Louis, MO, a local, peer-led outreach program incorporated a new rapid access (RA) to buprenorphine program.

Assessing the role of Berberine as an inhibitor of advanced glycation end products (AGEs) formation using in vitro and molecular interaction studies.

Glycation and aggregation of proteins have garnered more interest in recent years. Glycation leads to the formation of protein aggregates and advanced glycation ends (AGEs) that play crucial roles within several pathological conditions. The objective of our study is to gain a deeper understanding of the formation of AGEs and aggregates of human serum albumin (HSA) in the presence of methylglyoxal and the protective effects of the phytochemical berberine.

Tele-medicine and its impact on academic medical centers: A narrative review.

Telemedicine is a potential complementary modality with remarkable benefits for future healthcare delivery when incorporated appropriately. This review article examines the importance of telemedicine in various types of healthcare facilities and its utility in remote and underserved settings. PubMed, Google Scholar, Scopus, and Embase databases were used for the literature review.

A National Assessment of Pediatric Surgical Critical Care Fellowship Structure: Defining the Training Experience.

Background: Pediatric Surgical Critical Care (PSCC) is a unique specialty incorporating fundamental principles of surgical, neonatal, and pediatric critical care. This study aims to characterize the current landscape of PSCC training to identify opportunities for educational standardization and improvement.

Methods: An anonymous electronic survey-based assessment was distributed to the program directors (PDs) of all current ACGME-accredited PSCC fellowships (n = 14).

Fournier's Gangrene Severity Index and Charlson Comorbidity Index Predict Mortality, Intensive Care Unit Admission, and Length of Hospital Stay in Patients With Fournier's Gangrene: An Analysis of 264 Consecutive Patients.

Introduction Fournier's gangrene (FG) is a rapidly progressing necrotizing fasciitis. The Fournier's Gangrene Severity Index (FGSI), in conjunction with the Charlson Comorbidity Index (CCI), has been used as a mortality predictor during hospitalization. Patients with diabetes have also been shown to be at an increased risk for the development of FG.

SCOUT® radar reflectors for impalpable lesion localisation in the breast and axilla: our experience in the first 500 patients.

Aim: This study aimed to detail our experience of using SCOUT® radar reflector for lesion localisation in the breast and axilla.

Materials And Methods: This is a prospective cohort study describing our clinical experience with the first 500 patients who received SCOUT® to localise lesions in the breast and axilla (from 23 July 2020 to 4 April 2022). Study measures include patient demographics, lesion location, diagnostic pathways (screening or symptomatic), imaging, and surgical and pathology outcomes.

The Role of WNT5a and TGF-β1 in Airway Remodelling and Severe Asthma.

Background: Airway remodelling is a feature of severe asthma with airway epithelial damage observed frequently. We evaluated the role of WNT5a and TGF-β in asthmatic airway biopsies and in sputum and bronchial brushings assessed their role in remodelling.

Methods: WNT5a and TGF-β protein expression were assessed in the lamina propria epithelium of people with asthma (GINA 1-3, n-8 and GINA 4-5, n-14) and healthy subjects (n-9), alongside relevant remodelling markers.

Sexual Harassment in Academic Anesthesiology: A Survey of Prevalence, Sources, Impact, and Recommendations.

Background: A report by the American Association of Medical Colleges (AAMC) showed that academic anesthesiology has the highest prevalence of sexual harassment among specialties for both men and women. We aimed to explore the prevalence, sources, and impact of sexual harassment on anesthesiologists in academic centers in the United States and Canada. We also sought recommendations for its mitigation.

Mechanistic Insights into the Divergent Membrane Activities of a Viroporin from Chikungunya Virus and Its Transframe Variant.

Alphaviruses, a genus of vector-borne viruses in the family, encode a small ion-channel-forming protein, 6K, and its transframe variant (TF) during infections. Although 6K/TF have vital roles in glycoprotein transport, virus assembly, and budding, there is no mechanistic explanation for these functions. We investigated the distinct biochemical functionalities of 6K and TF from the mosquito-borne alphavirus, Chikungunya Virus.

Improved Adherence to Lipid Screening in the Pediatric Cardiology Clinic: A Quality Improvement Project.

Introduction: Lipid screening identifies at-risk patients to facilitate cardiovascular risk reduction. National pediatric guidelines recommend universal lipid screening between 9-11 and 17-21 years of age. We aimed to improve adherence to lipid screening for all age-appropriate outpatient pediatric cardiology visits from a baseline of 35% to 90% between November 2021 and July 2023.

Connecting the Dots: Exploring the Association Between Systemic Lupus Erythematosus and Thyroid Disorders.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease marked by chronic inflammation and tissue damage that impacts multiple organ systems and diminishes the quality of life. Among the frequent comorbidities in SLE, thyroid dysfunction, including hypothyroidism and hyperthyroidism, stands out due to its high prevalence and common autoimmune basis. This review examines the epidemiological, genetic, and immunological factors that link SLE with autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease.

The Root-Tuber Trypsin Inhibitor of Winged Bean and Its Anti-cancerous Activity Against Osteosarcoma Cell-Line.

Trypsin inhibitor from the root-tuber of underutilized legume Winged bean (Psophocarpus tetragonolobus (L.) DC.) (WbT-TI) was purified using ion exchange chromatography followed by size-exclusion chromatography.

Improving first responders' perceptions of overdose events and survivors through tailored occupational health-focused training co-facilitated by overdose survivors.

Background: First responders (law enforcement officers, emergency medical services, and firefighters) frequently interact with people who use drugs (PWUD). Based on the nature and outcomes of such encounters, these interactions have the potential either to reduce harm, or perpetuate it. Given increased funding and attention for first responder-led interventions involving PWUD, we must identify the most critical training for improving negative beliefs about these interventions and populations.

Association of and Genetic Variants With Schizophrenia in the Bangladeshi Population: A Case-Control Study.

Background And Aims: Schizophrenia (SCZ) is among the most persistent and devastating psychological problems. Different genetic polymorphisms are responsible for the predisposition of SCZ, and we screened (rs2071287, rs204993) and (rs2070673) polymorphisms in this study to find the connection with SCZ development.

Methods: We investigated a total of 420 samples (210 patients and 210 controls) and used the PCR-RFLP technique to genotype all SNPs.

Floristic diversity and species composition along altitudinal gradient in the alpine ecosystem of the cold desert region in Western Himalaya, India.

In India, the Trans-Himalayan zone lies in the rain shadow of the main Himalayan region and is usually described as a "high-altitude cold desert". These regions are represented by sparse but unique vegetation composition. The present study is an attempt to investigate the vegetation composition in the alpine ecosystem of the cold desert landscape of the Nelang Valley in Western Himalayas (Uttarakhand), India.

Behavioral and molecular effects of micro and nanoplastics across three plastic types in fish: weathered microfibers induce a similar response to nanosized particles.

Micro and nanoplastics (MNPs) are ubiquitous in the environment and have been detected in most ecosystems, including remote regions. The class of contaminants under the MNP umbrella is quite broad and encompasses variable polymer types, shapes, and sizes. Fibers are the most frequently detected in the environment, followed by fragments, but still represent only a small fraction of laboratory studies.

The impact of psychological well-being on academic performance among undergraduate dental students.

Objective: To assess the relationship between psychological wellbeing and academic performance among undergraduate dental students.

Methods: The analytical, cross-sectional study was done at a dental college in Rawalpindi, Pakistan, from January to July 2023, and comprised dental students after getting approval from Ethical Review Committee. Data on psychological wellbeing was collected using a short version of the Psychological Wellbeing Scale, assessing autonomy, environmental mastery, personal growth, positive relations with others, purpose in life, and selfacceptance.

Enhancing security in financial transactions: a novel blockchain-based federated learning framework for detecting counterfeit data in fintech.

Fintech is an industry that uses technology to enhance and automate financial services. Fintech firms use software, mobile apps, and digital technologies to provide financial services that are faster, more efficient, and more accessible than those provided by traditional banks and financial institutions. Fintech companies take care of processes such as lending, payment processing, personal finance, and insurance, among other financial services.

Investigating the effects of the ARG258HIS mutation on RAD51C in inherited Fanconi Anemia and cancer disease.

Fanconi anemia is a rare chromosomal instability disorder associated with developmental abnormalities, bone marrow failure, and a heightened susceptibility to leukemia and other cancers. It is an autosomal recessive genetic disorder, necessitating both parents to carry the faulty gene. Diagnostic methods include blood tests, chromosome breakage assessments, and genetic testing.

Utilization of AI - reshaping the future of food safety, agriculture and food security - a critical review.

Artificial intelligence is an emerging technology which harbors a suite of mechanisms that have the potential to be leveraged for reaping value across multiple domains. Lately, there is an increased interest in embracing applications associated with Artificial Intelligence to positively contribute to food safety. These applications such as machine learning, computer vision, predictive analytics algorithms, sensor networks, robotic inspection systems, and supply chain optimization tools have been established to contribute to several domains of food safety such as early warning of outbreaks, risk prediction, detection and identification of food associated pathogens.