Publications by authors named "Siddhartha Bera"
J Chem Inf Model
November 2022
Article Synopsis
- Alzheimer's Disease is a severe brain disorder causing neuron decay and lacks effective treatments, prompting research into new drug molecules.
- Researchers conducted molecular dynamics simulations to explore how a specific indanone-carbamate-based molecule impacts the aggregation of harmful Aβ peptides associated with the disease.
- The findings indicate that the inhibitor disrupts the structured β-sheet of Aβ peptides through hydrophobic interactions and can passively diffuse across lipid membranes, providing insights into potential therapeutic strategies.
