Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease.

Chronic obstructive pulmonary disease (COPD) is variable in its development. Lung microbiota and metabolites collectively may impact COPD pathophysiology, but relationships to clinical outcomes in milder disease are unclear. Identify components of the lung microbiome and metabolome collectively associated with clinical markers in milder stage COPD.

Pre-Clinical Model to Study Recurrent Venous Thrombosis in the Inferior Vena Cava.

Background: Patients undergoing deep vein thrombosis (VT) have over 30% recurrence, directly increasing their risk of post-thrombotic syndrome. Current murine models of inferior vena cava (IVC) VT model host one thrombosis event.

Objective: We aimed to develop a murine model to study IVC recurrent VT in mice.