Publications by authors named "Siddharth Reddy Soma"
ACS Appl Bio Mater
July 2024
Article Synopsis
- Visudyne is the only approved nanomedicine for photodynamic therapy, using a stable form of the drug BPD conjugated to a specific lysophospholipid, BPD-PC, which effectively targets cancer cells.
- The study compares BPD-PC incorporated in solid lipid nanoparticles (similar to the Spikevax vaccine) against traditional liposomal formulations, revealing that the solid lipid nanoparticles generate more singlet oxygen and maintain better stability by significantly reducing the leaching of BPD-PC.
- Despite different chemical properties, both formulations showed similar cellular uptake and phototoxicity against pancreatic cancer cells, but the solid lipid nanoparticles enhanced immunogenic cell death more effectively, suggesting potential for improved cancer therapies.
