Innovative berberine nanoethosomal vaginal in situ gel: Unraveling polycystic ovary syndrome treatment on female Wistar rats.

Purpose: The present work seeks to develop, assess and refine a nanoethosomal vaginal in situ gel containing Berberine, aimed at enhancing its efficacy in treating Poly Cystic Ovary Syndrome (PCOS). This formulation aims to augment drug permeation, enable controlled release kinetics, and mitigate oral adverse effects commonly associated with Berberine administration.

Method: Nanoethosomes formulated using diverse soya lecithin-ethanol concentrations within a 3 full-factorial-design, sought optimal formulations based on particle size and %entrapment-efficiency.

Formulation, optimization and evaluation of amisulpride-loaded niosomal intranasal gel for brain targeting.

To develop stable non-ionic surfactant vesicles containing amisulpride (AMS) to improve brain uptake via nose to brain mechanism. Niosomes were developed using a modified ethanol injection technique, optimized using 3 factorial design and evaluated for the vesicle size (VS), percent encapsulation efficiency (EE), zeta potential (ZP) and % cumulative drug release (%CDR). Optimized niosomes (Span-60: cholesterol ratio 0:1) showed 191.