Publications by authors named "Siddaram Nadigar"
Article Synopsis
- The pyridine core is vital in many FDA-approved drugs and EPA-regulated chemicals, serving as a key structural component in various applications like ligands and catalysts.
- Direct functionalization of pyridine is challenging due to its unstable nature and nitrogen's strong coordination, but recent advancements in regioselective C-H activation techniques show promise for improving this process.
- This review highlights innovative strategies for meta and para-C-H functionalization, discussing both their advantages and limitations, to encourage further developments in pyridine chemistry.
Angiogenesis is the hallmark of cancer progression driven by VEGF/VEGFR-2 signalling pathway, inhibition of which could be a solution to tackle the progression of tumour cells and thus arresting their growth. A novel class of pyrazoles was synthesized using arginine and dibromo ketones. Antiangiogenic activity was performed by yolk sac method.
View Article and Find Full Text PDFPeptide-based drugs are gaining significant momentum in the modern drug discovery, which is witnessed by the approval of new drugs by the FDA in recent years. On the other hand, small molecules-based drugs are an integral part of drug development since the past several decades. Peptide-containing drugs are placed between small molecules and the biologics.
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