Catalyst to cure: applications of a new copper-based nanocatalyst in organic synthesis and cancer treatment.

This research explores the diverse applications of copper(0) nanoparticles grafted onto boron carbon nitride nanosheets, using dill leaf extract as a natural reducing and stabilizing agent. This nanocatalyst efficiently catalyzes the synthesis of tetrazole and aniline derivatives, demonstrating good recyclability and promising potential in cancer therapy. By merging sustainability with innovation, this nanocatalyst offers transformative solutions in both synthesis and medical fields.

Metal complexes of backbone-halogenated imidazol-2-ylidenes.

In this manuscript, literature reports on mono- and di-halogen (F, Cl, Br, and I) substituted at positions 4 or/and 4,5 imidazol-2-ylidene (NHC) metal complexes are discussed: particularly, their structural diversity with various metals (groups 6-13), important physicochemical properties, catalytic and medicinal/biological applications are reviewed. To our knowledge, there are no literature reports on group 4 and 5 metal complexes with this type of NHC ligands. Halogenated imidazol-2-ylidene metal complexes deserve special attention because halogens are the classic electron donating groups (mesomerically) in conjugated aromatic/heteroaromatic ring systems, but electron withdrawing inductively.

NHCs silver complexes as potential antimicrobial agents.

NHCs (-heterocyclic carbenes) are generally used as organic ligands that can coordinate with metal ions like silver to form stable complexes. These complexes have shown enhanced antimicrobial properties compared to silver alone. This document provides an overview of the reported NHC-based silver derivatives (acetates, chlorides, bromides, and iodides) who possess antimicrobial activity.

Palladium Nanoparticles Grafted onto Phytochemical Functionalized Biochar: A Sustainable Nanozyme for Colorimetric Sensing of Glucose and Glutathione.

The devising and development of numerous enzyme mimics, particularly nanoparticles and nanomaterials (nanozymes), have been sparked by the inherent limitations imposed by natural enzymes. Peroxidase is one of the enzymes that is extensively utilized in commercial, medical, and biological applications because of its outstanding substrate selectivity. Herein, we present palladium nanoparticles grafted on (jackfruit) seed-derived biochar (BC-AHE@Pd) as a novel nanozyme to imitate peroxidase activity en route to the rapid and colorimetric detection of HO, exploiting -phenylenediamine as a peroxidase substrate.

Recent Advances in the Removal of Radioactive Iodine and Iodide from the Environment.

Iodine (I) in the form of iodide ions (I) is an essential chemical element in the human body. Iodine is a nonmetal that belongs to the VIIA group (halogens) in the periodic table. Over the last couple of centuries, the exponential growth of human society triggered by industrialization coincided with the use of iodine in a wide variety of applications, including chemical and biological processes.

Advances in the synthesis and applications of 2D MXene-metal nanomaterials.

MXenes, two-dimensional (2D) materials that consist of transition metal carbides, nitrides and/or carbonitrides, have recently attracted much attention in energy-related and biomedicine fields. These materials have substantial advantages over traditional carbon graphenes: they possess high conductivity, high strength, excellent chemical and mechanical stability, and superior hydrophilic properties. Furthermore, diverse functional groups such as -OH, -O, and -F located on the surface of MXenes aid the immobilization of numerous noble metal nanoparticles (NP).

Biogenic Silver Nanoparticles/Mg-Al Layered Double Hydroxides with Peroxidase-like Activity for Mercury Detection and Antibacterial Activity.

Over the past decade, the attention of researchers has been drawn to materials with enzyme-like properties to substitute natural enzymes. The ability of nanomaterials to mimic enzymes makes them excellent enzyme mimics; nevertheless, there is a wide berth for improving their activity and providing a platform to heighten their potential. Herein, we report a green and facile route for leaves extract-assisted synthesis of silver nanoparticles (Ag NPs) decorated on Mg-Al layered double hydroxides (Mg-Al-OH@TGLE-AgNPs) as a nanocatalyst.

Coumarin Triazoles as Potential Antimicrobial Agents.

Currently, in hospitals and community health centers, microbial infections are highly common diseases and are a leading cause of death worldwide. Antibiotics are generally used to fight microbial infections; however, because of the abuse of antibiotics, microbes have become increasingly more resistant to most of them. Therefore, medicinal chemists are constantly searching for new or improved alternatives to combat microbial infections.

Carbazole Derivatives as Potential Antimicrobial Agents.

Microbial infection is a leading cause of death worldwide, resulting in around 1.2 million deaths annually. Due to this, medicinal chemists are continuously searching for new or improved alternatives to combat microbial infections.

Comprehensive Review on Medicinal Applications of Coumarin-Derived Imine-Metal Complexes.

Coumarins are fused six-membered oxygen-containing benzoheterocycles that join two synthetically useful rings: α-pyrone and benzene. A survey of the literature shows that coumarins and their metal complexes have received great interest from synthetic chemists, medicinal scientists, and pharmacists due to their wide spectrum of biological applications. For instance, coumarin and its derivatives have been used as precursors to prepare a large variety of medicinal agents.

Antibacterial natural products from microbial and fungal sources: a decade of advances.

Throughout the ages the world has witnessed the outbreak of many infectious diseases. Emerging microbial diseases pose a serious threat to public health. Increasing resistance of microorganisms towards the existing drugs makes them ineffective.

Catalyst- and Additive-Free Approach to Constructing Benzo-oxazine, Benzo-oxazepine, and Benzo-oxazocine: O Atom Transfer and C═O, C-N, and C-O Bond Formation at Room Temperature.

An exclusive synthesis of benzo-oxazine, benzo-oxazepine, and benzo-oxazocine from aryl propanal and 2-(hydroxyamino)phenyl alcohol under metal-free conditions is described. O atom transfer and formation of new C═O, C-N, and C-O bonds occur at room temperature to form six-, seven-, and eight-membered heterocycles under one-pot reaction conditions without using an external oxidant and base. The photophysical properties are studied using ultraviolet-visible absorption and photoluminescence.

Medicinal applications of coumarins bearing azetidinone and thiazolidinone moieties.

Coumarins (2-chromen-2-ones), also known as benzopyran-2-ones, are a family of naturally occurring heterocyclic ring systems that contain a lactone moiety. Coumarins exhibit a wide range of well-studied pharmacological properties. Over the last few decades, as a result of advances in diverse oriented synthetic routes, physicochemical properties and numerous biological activities, coumarins have become globally studied molecules from various synthetic and medicinal chemists.

-heterocyclic carbene metal complexes as therapeutic agents: a patent review.

Introduction: Besides the well-established catalytic, synthetic and materials related applications of N-heterocyclic carbene (NHC) metal complexes, their use as therapeutics deserves a special attention. Many literature reports indicate that their bioactivity is superior to other organometallic compounds. The main focus of patent disclosures in this area is the elucidation of anticancer and antimicrobial activities of NHC transition metal complexes.

Single-atom nanozymes and environmental catalysis: A perspective.

The nanomaterials intrinsic enzyme-like activity has gained enormous traction since its discovery in 2007 by Gao and colleagues. The wide range of applications with nanozymes made it more attractive among the scientific community across the world. The area of artificial-enzymes is still evolving, with the development of Single-Atom Nanozymes (SANs), and there is a lot of opportunity in the design and development of SANs that has plenty of real-time applications.

Crystal structure and spectroscopic properties of ()-1,3-dimethyl-2-[3-(4-nitro-phen-yl)triaz-2-enyl-idene]-2,3-di-hydro-1-imidazole.

The title compound ()-1,3-dimethyl-2-[3-(4-nitro-phen-yl)triaz-2-enyl-idene]-2,3-di-hydro-1-imidazole, CHNO, has monoclinic (2/) symmetry at 100 K. This triazene derivative was synthesized by the coupling reaction of 1,3-di-methyl-imidazolium iodide with 1-azido-4-nitro benzene in the presence of sodium hydride (60% in mineral oil) and characterized by H NMR, C NMR, IR, mass spectrometry, and single-crystal X-ray diffraction. The mol-ecule consists of six-membered and five-membered rings, which are connected by a triazene moiety (-N=N-N-).

Continuous flow synthesis and antimicrobial evaluation of NHC* silver carboxylate derivatives of SBC3 in vitro and in vivo.

N-heterocyclic silver carbene compounds have been extensively studied and shown to be active agents against a host of pathogenic bacteria and fungi. By incorporating hypothesized virulence targeting substituents into NHC-silver systems via salt metathesis, an atom-efficient complexation process can be used to develop new complexes to target the passive and active systems of a microbial cell. The incorporation of fatty acids and an FtsZ inhibitor have been achieved, and creation of both the intermediate salt and subsequent silver complex has been streamlined into a continuous flow process.

Synthesis, molecular docking studies, and in vitro antimicrobial evaluation of piperazine and triazolo-pyrazine derivatives.

For this work, two series of new piperazine derivatives (3a-o) and triazolo-pyrazine derivatives (3p-t) were synthesized in a single-step reaction. All twenty adducts were obtained in good to high yields and fully characterized by H NMR, C NMR, IR, and mass spectrometry techniques. To further confirm the chemical identity of the adducts, a crystal of N-{[(4-chlorophenyl)-3-(trifluoromethyl)]-5,6-dihydro-[1,2,4]triazolo[4,3-a]}pyrazine-7(8H)-carboxamide (3t) was prepared and analyzed using X-ray crystallography.

Efficient and recyclable palladium enriched magnetic nanocatalyst for reduction of toxic environmental pollutants.

In this paper, highly stable, powerful, and recyclable magnetic nanoparticles tethered N-heterocyclic carbene-palladium(II) ((CH)-NHC-Pd@FeO) as magnetic nanocatalyst was successfully synthesized from a simplistic multistep synthesis under aerobic conditions through easily available low-cost chemicals. Newly synthesized (CH)-NHC-Pd@FeO magnetic nanocatalyst was characterized from various analytical tools and catalytic potential of the (CH)-NHC-Pd@FeO magnetic nanocatalyst was studied for the catalytic reduction of toxic 4-nitrophenol (4-NP), hexavalent chromium (Cr(VI)), Methylene Blue (MB) and Methyl Orange (MO) at room temperature in aqueous media. UV-Visible spectroscopy was employed to monitor the reduction reactions.

Controlled Synthesis of Palladium Nanocubes as an Efficient Nanocatalyst for Suzuki-Miyaura Cross-Coupling and Reduction of -Nitrophenol.

Anisotropic nanocatalysts have attracted considerable attention in comparison to bulk/nanocatalysts for their enhanced activity and reactivity. The demand toward anisotropic palladium (Pd) nanostructures has increased rapidly in the field of catalysis. Pd is a well-known active catalyst for several carbon-carbon (C-C) cross-coupling reactions; among them, the Suzuki-Miyaura cross-coupling reaction is one of the most versatile and dominant methods for constructing the extraordinarily useful unsymmetrical biaryls and also for hydrogenation of organic contaminants like -nitrophenol (-NP).

Catalyst-Free Regioselective [3+2] Cycloadditions of α,β-unsaturated N-arylnitrones with Alkenes to Access Functionalized Isoxazolidines: A DFT Study.

The catalyst-free regioselective [3+2]-cycloaddition of α,β-unsaturated N-arylnitrones with alkenes are developed. The series of synthetically important functionalized isoxazolidines are prepared in good to excellent yields by step economic pathway under ligand and transition-metal-free conditions. The regioselective cycloaddition pathway supported by control experiment and computational study.

Enhancing Ru(II)-Catalysis with Visible-Light-Mediated Dye-Sensitized TiO Photocatalysis for Oxidative C-H Olefination of Arene Carboxylic Acids at Room Temperature.

Erythrosine B sensitized TiO photocatalysis has been combined with Ru(II)-catalysis to accomplish an oxidative olefination/annulation of benzoic acids with activated olefins under mild conditions that tolerates useful functionalities, such as halides, free hydroxy, acetamido, etc. The morphology of the photocatalyst is unaffected during the reaction and it can be reused. Mechanistic studies favor the involvement of a photo-induced single electron transfer process.

New Urea Derivatives as Potential Antimicrobial Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies.

A series of new urea derivatives, containing aryl moieties as potential antimicrobial agents, were designed, synthesized, and characterized by H NMR, C NMR, FT-IR, and LCMS spectral techniques. All newly synthesized compounds were screened in vitro against five bacterial strains ( and ) and two fungal strains ( and ). Variable levels of interaction were observed for these urea derivatives.

Design, synthesis, and molecular docking study of new piperazine derivative as potential antimicrobial agents.

Herein, we describe the successful design and synthesis of seventeen new 1,4-diazinanes, compounds commonly known as piperazines. This group of piperazine derivatives (3a-q) were fully characterized by H NMR, C NMR, FT-IR, and LCMS spectral techniques. The molecular structure of piperazine derivative (3h) was further established by single crystal X-ray diffraction analysis.

From agriculture residue to catalyst support; A green and sustainable cellulose-based dip catalyst for CC coupling and direct arylation.

The core characteristics of a perfect catalyst include good activity, simple design, excellent stability, easy recovery from reaction mixture, recyclability, and have the provision for easy scale up. The ease in synthesis, recyclability and scale up makes the dip catalyst a major contender in this regard which possess most of the aforementioned characteristics. In this work, we report a dip catalyst made of cellulose, isolated from agriculture residue (sugarcane bagasse), in which biogenically synthesized palladium nanoparticles were dispersed.