Publications by authors named "Sicheng Luo"
Identify Non-mutational p53 Functional Deficiency in Human Cancers.
Genomics Proteomics Bioinformatics
September 2024
An accurate assessment of p53's functional status is critical for cancer genomic medicine. However, there is a significant challenge in identifying tumors with non-mutational p53 inactivations that are not detectable through DNA sequencing. These undetected cases are often misclassified as p53-normal, leading to inaccurate prognosis and downstream association analyses.
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- The study focuses on creating innovative Pt-based nanostructures with controlled compositions to improve their effectiveness as electrocatalysts, specifically through the development of unique Pt@Pt-skin PtNi core-shell framework nanowires.
- These nanowires exhibit a specialized structure with a thin Pt core and a mesoporous shell, resulting in high electrocatalytic activity and stability, particularly during the oxygen reduction reaction.
- The design allows for better accessibility to catalytic sites and reduced interaction with oxygenated species, leading to impressive performance metrics, including minimal activity decay after extensive cycling.
Single-cell studies have delineated cellular diversity and uncovered increasing numbers of previously uncharacterized cell types in complex tissues. Thus, synthesizing growing knowledge of cellular characteristics is critical for dissecting cellular heterogeneity, developmental processes and tumorigenesis at single-cell resolution. Here, we present Cell Taxonomy (https://ngdc.
View Article and Find Full Text PDFLncRNAWiki, a knowledgebase of human long non-coding RNAs (lncRNAs), has been rapidly expanded by incorporating more experimentally validated lncRNAs. Since it was built based on MediaWiki as its database system, it fails to manage data in a structured way and is ineffective to support systematic exploration of lncRNAs. Here we present LncRNAWiki 2.
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