Publications by authors named "Sichen Guo"
Objective: The aim of this study was to investigate the gut microbial signatures and related pathophysiological implications in patients with Cushing's disease (CD).
Design And Methods: Twenty-seven patients with CD and 45 healthy controls were enrolled. Based on obtained metagenomics data, we performed correlation, network study, and genome interaction group (GIG) analysis.
Article Synopsis
- Craniopharyngioma (CP) is a benign brain tumor that can severely impact the hypothalamus, leading to serious health issues like obesity and cognitive impairments.
- Research shows that patients with CP have an altered gut microbiome, with higher levels of certain bacteria (Clostridium, Eubacterium) linked to negative health effects like dyslipidemia and cognitive decline.
- The study also found that changes in the microbiome are connected to up-regulation of purine metabolism and redox imbalances, suggesting these factors may contribute to the development and worsening of hypothalamic comorbidities associated with CP.