Antibacterial effect and mechanisms of action of forsythoside B, alone and in combination with antibiotics, against Acinetobacter baumannii and Pseudomonas aeruginosa.

Background: Antibiotic resistance complicates infection treatments. Natural products, such as phenylethanoid glycosides, including forsythoside B (FB), are gaining attention in clinical use as alternative treatments, either alone or in combination with antibiotics.

Purpose: To investigate the antibacterial effects and mechanisms of FB alone and in combination with antibiotics against Acinetobacter baumannii and Pseudomonas aeruginosa.