Functional network changes associated with sleep deprivation and fatigue during simulated driving: validation using blood biomarkers.

Objective: Network analysis of electroencephalograph (EEG) signals to study the effect of fatigue and sleep deprivation in human drivers and its validation using blood biochemical parameters.

Methods: We present a new method of detection of human fatigue and sleepiness by studying the variation of functional interdependencies among EEG signals from various channels. An experiment has been designed to induce fatigue in 12 subjects through several stages over 36 h of sleep deprivation.