Adolescent and adult participation in an HIV vaccine trial preparedness cohort in South Africa.

Purpose: The importance of involving adolescents in HIV prevention trials has been recognized, but there have been few experiences reported from sub-Saharan Africa. We analyzed adult and adolescent data from a cohort study conducted to assess the feasibility of involving adolescents and adults in HIV vaccine-related studies.

Methods: Two hundred HIV-negative participants aged 16 to 40 years were enrolled, including 86 (43%) adolescents.