Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats.

Inflammation-mediated alterations in glutamate neurotransmission constitute the most important pathway in the pathophysiology of various brain disorders. The excessive signalling of glutamate results in excitotoxicity, neuronal degeneration, and neuronal cell death. In the present study, we investigated the relative efficacy of black cumin () oil with high (5 % w/w) and low (2 % w/w) thymoquinone content (BCO-5 and BCO-2, respectively) in alleviating ibotenic acid-induced excitotoxicity and neuroinflammation in Wistar rats.

The anti-inflammatory properties of the methanolic extract of Linn. against prostate enlargement in Wistar rats.

In different parts of the world, Linn. () is used for its medicinal properties. The present study examined the effects of a methanolic extract of Linn.

The effects of oral administration of curcumin-galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study.

Overview: A novel highly bioavailable curcumin-galactomannan (CGM) formulation was shown to have improved blood-brain-barrier (BBB) permeability of free curcuminoids in animal models; however, this has not been established in humans. The present study was conducted to determine the functional effects of CGM on brain waves in healthy individuals, owing to its BBB permeability.

Methods: A total of 18 healthy volunteers aged 35-65 were randomly assigned to consume 500 mg CGM, Unformulated curcumin (UC) or Placebo capsules twice daily for 30 days.

Effect of hydro-alcoholic root extract of Plumbago zeylanica l alone and its combination with aqueous leaf extract of Camellia sinensis on haloperidol induced parkinsonism in wistar rats.

Background: Herbal medicines have been used to treat PD in ancient medical systems in Asian countries such as India, China, Japan and Korea based on their own anecdotal or experience-based theories. Mucuna pruriens commonly known asvelvet beans, or cow itch, are used in case of spasms associated with Parkinsonism.

Purpose: To investigate the antiparkinsonism activity of hydro alcoholic root extract of P.

Role of cytokines in anti-implantation activity of H2 receptor blockers in albino Wistar rats.

In this study, the negative effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) on the immune system and body weight gain of rats and the preventive effects of curcumin were examined. For this purpose, 3-4 months old 128 Wistar albino rats with 280-310g body weights were used. The 2microg/kg dose of 2,3,7,8-TCDD and 100mg/kg dose of curcumin were dissolved in corn oil and orally given to the rats found in the experimental and control groups.