Publications by authors named "Sibel Yel"
Objective: In patients with end-stage kidney disease, kidney transplantation is the kidney replacement therapy option that provides the most successful survival. However, immunosuppression agents administered after kidney transplantation can increase the risk of opportunistic infections. Microsporidia are obligate intracellular pathogens that can be fatal in immunosuppressed patients.
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- * Despite treatment and normal initial tests, she experienced recurring kidney stones and unusual urinary infections, prompting further investigation into metabolic disorders.
- * Genetic testing ultimately revealed a mutation in the AGXT gene, leading to a diagnosis of primary hyperoxaluria type 1, highlighting the coexistence of two rare genetic conditions in the same child.
Pediatric kidney care experience after the 2023 Türkiye earthquake.
Nephrol Dial Transplant
August 2024
Article Synopsis
- Two devastating earthquakes in Türkiye on February 6, 2023, resulted in significant injuries to 903 children, with a focus on crush syndrome-related acute kidney injury (Crush-AKI) and mortality.
- The study tracked various factors, including the time under rubble, treatment protocols, and patient outcomes, revealing that Crush-AKI developed in 36% of the patients, and over half required dialysis.
- Key findings included that serum levels of creatine phosphokinase above 20,950 U/L and inadequate initial intravenous fluid volume were linked to Crush-AKI, and most deaths occurred among those with Crush-AKI within the first four days of admission.
Article Synopsis
- C3 glomerulopathy (C3G) is a kidney disease influenced by genetic factors, and this study explores the differences in clinical outcomes among pediatric patients with and without mutations in complement-related genes.
- Among 60 patients studied, 17 had genetic mutations with the CFH gene being the most common; those with mutations typically showed asymptomatic urinary issues and were diagnosed at an older age.
- Despite differences in presentation, both groups had similar long-term kidney survival and response to mycophenolate mofetil treatment, indicating that genetic mutations may not significantly impact treatment outcomes.
Article Synopsis
- Myelomeningocele (MMC) is a condition that affects many kids in developing countries like Turkey, and it can lead to kidney problems known as chronic kidney disease (CKD).
- A study in Turkey looked at children with MMC to find out how many had different stages of CKD and what factors made their kidney health worse.
- The results showed that 5.3% of the kids had CKD stage 5, and certain medical conditions were linked to an increased risk of serious kidney problems. To help these kids, doctors suggest taking early action in managing their bladder issues to prevent kidney failure.
Article Synopsis
- The study focuses on urinary tract infections (UTIs) in children and investigates the potential use of soluble Toll-like receptors (sTLR4, sTLR5) and interleukin 8 (IL-8) as biomarkers for diagnosing UTIs.
- It involved 520 children, including those with UTIs, non-UTI infections, and healthy controls, measuring urine and serum levels of the biomarkers before and after treatment.
- Results show that urine sTLR4 levels are higher in UTI patients, with a cut-off level identified to predict UTIs, especially higher in cases of pyelonephritis compared to cystitis, and decreasing post-treatment.
Article Synopsis
- The study looked at why doctors requested ANA tests for kids with potential autoimmune diseases and how well those tests worked.
- Out of 3,812 kids tested, about 27% had positive ANA results, with juvenile idiopathic arthritis being the most common diagnosis.
- The study found that the ANA test wasn't very reliable for diagnosing these diseases, so doctors should think carefully before using it.
While 44-83% of children with steroid-resistant nephrotic syndrome (SRNS) without a proven genetic cause respond to treatment with a calcineurin inhibitor (CNI), current guidelines recommend against the use of immunosuppression in monogenic SRNS. This is despite existing evidence suggesting that remission with CNI treatment is possible and can improve prognosis in some cases of monogenic SRNS. Herein, our retrospective study assessed response frequency, predictors of response and kidney function outcomes among children with monogenic SRNS treated with a CNI for at least three months.
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- A new study looked at a special urine test called uHSP70 to help tell if kids have a urinary tract infection (UTI) instead of just using regular tests that might not be very reliable.
- The study involved 802 kids and found that uHSP70 levels were much higher in kids with UTI compared to those with other infections or who were healthy.
- Using uHSP70 could help doctors correctly diagnose UTIs and might stop about 80% of kids from getting unnecessary antibiotics.
Evaluation of the Claria sharesource system from the perspectives of patient/caregiver, physician, and nurse in children undergoing automated peritoneal dialysis.
Pediatr Nephrol
February 2023
Article Synopsis
- - The study examines the perceptions of patients, caregivers, nurses, and physicians regarding the automated peritoneal dialysis system (Homechoice with Claria sharesource system - CSS), focusing on its advantages and disadvantages for home treatment monitoring.
- - Questionnaires were filled out by 30 patients/caregivers, 22 pediatric nephrologists, and 15 PD nurses, revealing that most healthcare professionals believe CSS enhances patient monitoring and saves time, although many nurses felt other doctors weren't familiar with it.
- - While 90% of patients reported feeling safer due to constant monitoring, only 20% noticed reduced hospital visits, highlighting the need for more extensive research to fully understand CSS's impact on patient quality of life.
We evaluated the demographic features, etiologic risk factors, treatment strategies, and outcome of the infants and children with urolithiasis (UL). A retrospective multicenter study was conducted including 23 Pediatric Nephrology centers in Turkey. The medical records of 2513 children with UL were reviewed.
View Article and Find Full Text PDFBackground: Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors, and follow-up results of patients with NC in Turkey.
Methods: Patients diagnosed with NC in the pediatric nephrology Department Units of 19 centers from all geographical regions of Turkey over a 10-year period (2010-2019) were included in the study.
Background: Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN.
Patients, Design And Setting: We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey.
Background: Erythropoiesis-stimulating agents (ESAs) are used to treat anemia in CKD. Erythropoietin resistance index (ERI) is a useful tool used to evaluate the response to ESAs. In this study, we aimed to evaluate the causes of high ERI in children undergoing peritoneal dialysis (PD).
View Article and Find Full Text PDFBackground: Having a low nephron number is a well-known risk factor for hypertension. There is an inverse relationship between the filtration surface area and systemic hypertension. A significant percentage of masked hypertension can be detected in children with nephron loss by ambulatory blood pressure monitoring (ABPM).
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- The study focuses on seven patients who were admitted to a pediatric rheumatology clinic due to severe extremity pain linked to elemental mercury intoxication.
- Mercury is a toxic heavy metal that can severely impact various organs, with the brain being a primary target, but it also affects peripheral nerves, kidneys, and immune function.
- Treatments included Dimercaptosuccinic acid and metalcaptase, highlighting the importance of recognizing mercury poisoning in cases of unexplained pain to prevent significant health complications.
Epidermolysis bullosa (EB) encompasses a clinically and genetically heterogeneous group of rare inherited diseases characterized by marked mechanical fragility of epithelial tissues with blistering and erosions following minor trauma. Amyloidosis is one of the most important complications of EB mostly seen in recessive dystrophic EB (RDEB) patients and can involve the kidney, bowel, liver, and also respiratory system. Herein, we present a child, who is probably the youngest case of genetically diagnosed RDEB, complicated with amyloidosis reported in literature.
View Article and Find Full Text PDFObjective: To evaluate the efficacy and complications of mini-percutaneous nephrolithotomy (PCNL) surgery using 14-20 Fr access sheaths in pediatric patients, as well as the results of postoperative stone analysis and metabolic urine analysis.
Material And Methods: We retrospectively evaluated the records of 206 pediatric patients (232 kidney units) who underwent mini-PCNL for kidney stones in our clinic between February 2011 and December 2018. We evaluated the demographic characteristics, complications, stone-free rates, and the results of chemical analysis and urinary metabolic analysis.
A new semiquantitative classification (SQC) for pediatric Henoch-Schönlein nephritis (HSN) was defined recently. The outcomes of pediatric HSN patients are reevaluated according to the new classification. Primary kidney biopsies from 80 HSN patients were scored using the new SQC.
View Article and Find Full Text PDFA 6-year-old Syrian boy presented with complaints of facial dysmorphism and difficulty of walking. He had coarse face, macrocephaly, pectus carinatum, x-bain deformity, kyphosis, corneal clouding, and claw hand deformity. Galactose-6 sulphatase enzyme level was 0.
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