Publications by authors named "Sibel Kilicoglu"
Background: The aim of the study is to evaluate in vivo and in vitro effects of etanercept, a soluble tumor necrosis factor receptor, on the contractile responses of superior mesenteric artery in an experimental mesenteric ischemia and reperfusion model.
Material And Methods: After obtaining animal ethics committee approval, 24 Sprague-Dawley rats were allocated to three groups. Control group (Gr C, n = 6) underwent a sham operation, whereas ischemia/reperfusion and treatment groups underwent 90 min ischemia and 24-h reperfusion (Gr I/R, n = 12; Gr I/R+E, n = 6).
Purpose:: To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model.
Methods:: Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1.
Behçet's disease (BD) is a chronic, relapsing, multisystemic inflammatory disorder with unanswered questions regarding its etiology/pathogenesis and classification. Distinct manifestation based subsets, pronounced geographical variations in expression, and discrepant immunological abnormalities raised the question whether Behçet's is "a disease or a syndrome". To answer the preceding question we aimed to display and compare the molecular mechanisms underlying distinct subsets of BD.
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- CLEC12A is a receptor that detects monosodium urate crystals, which cause gout, and serves to regulate inflammation by inhibiting immune cell functions.
- There is a hypothesis that lower levels of CLEC12A contribute to the exaggerated inflammatory responses seen in both Behçet's syndrome and gout, with evidence linking CLEC12A expression and immune responses.
- Research suggests that colchicine, a common treatment for both conditions, may help prevent the downregulation of CLEC12A, potentially offering insights into new treatments and understanding of disease mechanisms.
Liver ischemia reperfusion injury (IRI) is an important pathologic process leading to bodily systemic effects and liver injury. Our study aimed to investigate the protective effects of diosmin, a phlebotrophic drug with antioxidant and anti-inflammatory effects, in a liver IRI model. Forty rats were divided into 4 groups.
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- The study investigates the effectiveness of two pulmonary surfactants, poractant and beractant, in preventing postoperative adhesions after abdominal surgery, using an experimental model with female rats.
- Rats were divided into three groups: one received no treatment, while the other two received different surfactants before the surgical incision was closed.
- Results showed that both surfactants significantly reduced adhesion scores compared to the control group, with beractant showing a slightly better outcome than poractant, although not statistically significant.
Aim: To evaluate the effect of propolis administration on the healing of colon anastomosis with light and transmission electron microscopes.
Methods: Forty-eight Wistar-Albino female rats were divided into two groups and had colon resection and anastomosis. In group I, rats were fed with standard rat chow pre- and postoperatively.
Background: This study was designed to examine the effects of propolis on the liver and biliary system when used as a scolicidal agent.
Materials And Methods: Thirty Wistar-Albino rats were divided into two groups. Propolis and 0.
Aim: To investigate the effects of propolis on bacterial translocation and ultrastructure of intestinal morphology in experimental obstructive jaundice.
Methods: Thirty Wistar-Albino male rats were randomly divided into three groups, each including 10 animals: group I, sham-operated; group II, ligation and division of the common bile duct (BDL); group III, BDL followed by oral supplementation of propolis 100 mg/kg per day. Liver, blood, spleen, mesenteric lymph nodes, and ileal samples were taken for microbiological, light and transmission electron microscopic examination on postoperative 7th d after sacrification.
Glutamine is considered a nonessential amino acid, but it may be conditionally essential in patients with catabolic conditions. For centuries, researchers have looked for ways to promote and accelerate fracture healing. This controlled animal study examines the effects of glutamine on fracture healing.
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