Publications by authors named "Sibel Aydın"
Article Synopsis
- The study aimed to determine effective cutoff scores for the Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) based on disease activity measures in patients with PsA.
- Using data from the ReFlaP study, researchers analyzed scores to define disease states such as remission and varying impact levels, employing statistical methods to establish these cutoffs.
- Results indicated that the PsAID12 score had high diagnostic performance against established benchmarks, but further validation and expert consensus are needed to confirm the proposed cutoffs for clinical use.
Article Synopsis
- - The case report highlights the first global use of the Hybrid System from Spectrum Medical in a heart transplant, showcasing its safety and efficacy compared to traditional cardiopulmonary bypass systems that increase blood exposure to air.
- - A 41-year-old male with dilated cardiomyopathy underwent a heart transplant using the Hybrid System, showing promising perioperative and postoperative outcomes due to his ideal candidacy.
- - The findings suggest that the Hybrid System could improve surgical results in cardiac surgery, though further studies are needed to validate its effectiveness in routine procedures.
Objective: We aimed to assess the following: (1) the frequency of axial spondyloarthritis (axSpA) according to extra-articular presentation and HLA-B27 status, (2) clinical and imaging features that distinguish axSpA from non-axSpA, and (3) the impact of magnetic resonance imaging (MRI) on diagnosis and classification of axSpA.
Methods: The Screening for Axial Spondyloarthritis in Psoriasis, Iritis, and Colitis (SASPIC) study enrolled patients in two multicenter cohorts. Consecutive patients with undiagnosed chronic back pain attending dermatology, ophthalmology, and gastroenterology clinics with psoriasis (PsO), acute anterior uveitis (AAU), or inflammatory bowel disease (IBD) were referred to a local rheumatologist with special expertise in axSpA for a structured diagnostic evaluation.
Entheses have the challenging task of transferring biomechanical forces between tendon and bone, two tissues that differ greatly in composition and mechanical properties. Consequently, entheses are adapted to withstand these forces through continuous repair mechanisms. Locally specialized cells (mechanosensitive tenocytes) are crucial in the repair, physiologically triggering biochemical processes to maintain hemostasis.
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- Ultrasound (US) is a valuable tool for detecting and monitoring various pathologies associated with psoriatic arthritis (PsA), helping in clinical decision-making.
- The GRAPPA US working group held sessions at their annual meeting in Dublin, presenting topics like the Diagnostic Ultrasound Enthesitis Tool (DUET) and comparing small hand-held ultrasound devices with traditional console machines.
- The group also discussed the current state of research on hand-held ultrasound in psoriatic diseases, identifying gaps and suggesting directions for future studies.
At the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2023 annual meeting, members were updated on a number of ongoing activities during the key project update session. These activities included the Axial Involvement in Psoriatic Arthritis (AXIS) cohort, the Axial Psoriatic Arthritis Molecular and Clinical Characterization study, the Diagnostic Ultrasound Enthesitis Tool (DUET) study, the Sex- and Gender-Based Analysis of the Effectiveness of Advanced Therapies in Psoriatic Arthritis (SAGE-PsA) study, the Health Initiatives in Psoriasis and Psoriatic Arthritis Consortium European States (HIPPOCRATES), the GRAPPA slide library, and the GRAPPA treatment recommendations.
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- The objective of the study is to create updated treatment guidelines for managing axial spondyloarthritis (axSpA) in Canada.
- The recommendations were developed by a diverse panel through a careful process, using existing guidelines and ensuring they fit within the Canadian context, while also considering health equity.
- A total of fifty-six recommendations were made covering various aspects of axSpA management, including treatment for different stages of the disease and considerations for monitoring and ethics, and these guidelines will be continually updated as new information emerges.
Objectives: We aimed to explore the radiographic definitions of types of New Bone formation (NBF) by focusing on the terminology, description and location of the findings.
Methods: Three systematic literature reviews were conducted in parallel to identify the radiographic spinal NBF definitions for spondyloarthritis (SpA), Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Osteorathritis (OA). Study characteristics and definitions were extracted independently by two reviewers.
Objectives: The main objective was to generate a GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis and to test its reliability. To this end, we assessed the validity, feasibility and applicability of ultrasound assessment of finger entheses to incorporate them into the scoring system.
Methods: The study consisted of a stepwise process.
Purpose: Enthesitis is a key manifestation of psoriatic arthritis (PsA) and spondyloarthritis (SpA) and is considered to be the tissue where the disease initiates. Enthesitis leads to pain and substantial limitations in patients with PsA. Treatment is key in achieving remission or minimal disease activity.
View Article and Find Full Text PDFThe Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) ultrasound (US) steering committee provided an update at GRAPPA's 2022 annual meeting on activities to enable earlier diagnosis of psoriatic arthritis. An update of the Diagnostic Ultrasound Enthesitis Tool (DUET) study included preliminary reliability results for US enthesitis elementary lesions. Common scanning pitfalls were reviewed.
View Article and Find Full Text PDFObjective: The coronavirus disease 2019 (COVID-19) pandemic created challenges for patients with RA. We examined the potential impact of the pandemic on patient-reported outcomes (PROs), disease activity and medication profiles, comparing the periods pre-pandemic and during the pandemic.
Methods: Patients enrolled in the Ontario Best Practices Research Initiative were included if they had at least one visit to a physician or study interviewer within 12 months before and after the start of pandemic-related closures in Ontario (15 March 2020).
Article Synopsis
- The study assessed the effects of sex on the effectiveness, safety, and persistence of tofacitinib in patients with psoriatic arthritis, using data from two phase 3 trials.
- Findings showed that while tofacitinib was effective for both males and females at 3 months, women were less likely to achieve minimal disease activity compared to men, likely because of differences in health status at the start.
- Both sexes experienced similar rates of adverse effects and discontinuation, indicating that tofacitinib's safety profile and retention rates were comparable regardless of sex.
Article Synopsis
- The study aimed to evaluate the reliability of ultrasound (US) muscle echogenicity assessments in patients with rheumatic diseases, involving 42 rheumatologists and 2 radiologists analyzing images and clips from 64 patients and 8 healthy subjects.
- Results showed that a semi-quantitative scale had moderate inter-reliability and substantial intra-reliability, while a continuous quantitative measurement ("VAS echogenicity") exhibited high reliability in both observer types.
- Overall, the findings confirmed good inter and intra-reliability of ultrasound assessments for muscle echogenicity in this patient group, suggesting consistency in evaluation methods across different observers.
Article Synopsis
- The study evaluated the mortality rates of patients with Psoriatic Arthritis (PsA) before and during the COVID-19 pandemic by analyzing data from a Turkish registry linked to the Cause of Death Registry.
- Findings revealed that the crude mortality rate in PsA patients doubled during the pandemic, with noticeable increases in both genders but more significant in females.
- The research concluded that pre-pandemic mortality rates for PsA were similar to the general population, but the pandemic has raised concerns about a potential increased mortality risk for PsA patients due to COVID-19, warranting further investigation.
Objectives: To explore patient-defined flares in psoriatic arthritis (PsA), compared to an increase in disease activity in psoriatic arthritis (DAPSA) and to analyze the validity of a patient-reported flare question.
Methods: ReFlap (NCT03119805) was a longitudinal study in 14 countries of consecutive patients with definite PsA. Patients were seen twice in the context of usual care, 4.
Objective: Ultrasound (US) is increasingly used to evaluate enthesitis. One of the US features of enthesitis is thickening. However, there is no consensus on how the entheseal thickening needs to be defined, and existing cut-off levels have been criticized for being frequently positive in healthy controls (HCs).
View Article and Find Full Text PDFObjective: This literature review aimed to identify the most efficacious current interventions for dactylitis and provide up-to-date scientific evidence to support the 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) recommendations on the management of psoriatic arthritis.
Methods: Original articles published from 2013 to 2020, registered in MEDLINE, Embase, and Cochrane Library, describing interventional trials and reporting dactylitis-related outcomes were included. The 20 members of the GRAPPA dactylitis group were divided into 9 subgroups according to treatment, and members of each group independently extracted data from articles/abstracts corresponding to their group by using a standardized data extraction form.
Objective: To systematically review the measurement properties of outcome instruments used in large-vessel vasculitis (LVV).
Methods: MEDLINE, Embase, Cochrane, and Scopus databases were searched for studies published from inception to July 14, 2020, that addressed measurement properties of instruments used in giant cell arteritis (GCA) and Takayasu arteritis (TA). The measurement properties of the instruments identified were collected following the Outcome Measures in Rheumatology (OMERACT) and Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) frameworks.
Objectives: Patient care can vary substantially by country. The objective was to explore differences in psoriatic arthritis (PsA) across countries for disease activity, impact and treatments.
Methods: A cross-sectional analysis of 13 countries from the Remission/Flare in PsA study (NCT03119805) of consecutive adult patients with definite PsA was performed.