Publications by authors named "Sibeen Kim"

Trauma during pregnancy poses a potentially tragic risk to both the fetus and mother, making its management particularly challenging. Here, we present the case of a 35-year-old woman at 34 weeks and 2 days gestation who was in a motor vehicle accident and subsequently suffered placental abruption and underwent an emergency cesarean section. We also present a review of traumatic placental abruption and its epidemiology.

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  • * One particular compound showed excellent performance with effective cross-linking, a stable electrochemical potential, and strong durability, making it ideal for sensor applications.
  • * The compound demonstrated consistent current levels in serum, effectively detecting doxorubicin, thus indicating its potential for developing reliable and sensitive sensors in clinical settings.
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  • The development of silicon (Si) materials is crucial for advancing various technologies like semiconductors and solar cells, presenting significant production challenges.
  • The study reveals that using molten AlCl salt during the thermochemical reduction of silicon oxides can enhance the reduction process, particularly with specific metals like magnesium (Mg).
  • The findings suggest that the choice of metal affects the properties of the final silicon product and allows for more efficient, cost-effective production at lower temperatures (around 250 °C).
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Aim: Staging surgery in early stage endometrial cancer has been shown to be feasible and safe with minimally invasive surgery (MIS) in many previous studies. However, there is limited literature on MIS's safety in advanced stages. This study aims to identify factors associated with survival in stage III endometrial cancer and investigate survival differences based on surgical approach.

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Reverse total shoulder arthroplasty (RSA) has emerged as a promising treatment option for rotator cuff tear arthropathy. However, concerns persist regarding horizontal rotational dysfunction after RSA. While many studies focus on improving external rotation after RSA, limited attention has been paid to internal rotation.

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This study examined the case of 27-year-old female who underwent orthognathic surgery to correct class 3 malocclusion, resulting in an unnatural smile. The research aimed to assess the efficacy of non-invasive treatment in enhancing facial muscle movement during smiling to achieve a natural smile. The patient received eight sessions of treatment using non-invasive devices, and facial assessment were conducted using three-dimensional scanner (Morpheus 3D Scanner) to evaluate facial features in both relaxed and maximum smile states pre- and post-treatment.

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Rare diseases, though individually uncommon, collectively affect millions worldwide. Genomic technologies and big data analytics have revolutionized diagnosing and understanding these conditions. This review explores the role of genomics in rare disease research, the impact of large consortium initiatives, advancements in extensive data analysis, the integration of artificial intelligence (AI) and machine learning (ML), and the therapeutic implications in precision medicine.

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  • The RNA-binding protein HuR is crucial in cancer progression, often preventing cell death, and its inhibition can lead to cancer cell death, which is not fully understood.
  • The study explored the effects of the small molecule inhibitor KH-3 on various cancer cell lines, particularly breast and prostate cancers, finding that it induced cell death through apoptotic mechanisms, autophagy, and ferroptosis.
  • KH-3's effectiveness was confirmed in mouse models and was linked to reduced levels of HuR target proteins involved in cell survival, suggesting that inhibiting HuR may serve as a potential cancer treatment strategy.
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V(D)J recombination secures the production of functional immunoglobulin (Ig) genes and antibody diversity during the early stages of B-cell development through long-distance interactions mediated by cis-regulatory elements and trans-acting factors. O-GlcNAcylation is a dynamic and reversible posttranslational modification of nuclear and cytoplasmic proteins that regulates various protein functions, including DNA-binding affinity and protein-protein interactions. However, the effects of O-GlcNAcylation on proteins involved in V(D)J recombination remain largely unknown.

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  • Single-cell and single-nucleus genomic techniques offer unbiased insights into cellular diversity and function, especially in the nervous system.
  • The concept of a molecular cell atlas is explored, emphasizing how single-cell omics can help formulate hypotheses about cell changes during development and disease.
  • Key considerations for study design, implementation, and awareness of potential limitations and challenges are discussed to improve research outcomes.
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Extracellular vesicles (EVs) transport biomolecules that mediate intercellular communication. We previously showed that EVs contain DNA (EV-DNA) representing the entire genome. However, the mechanism of genomic EV-DNA packaging and its role in cancer remain elusive.

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Maintaining precise intragastric pressure during gastrointestinal endoscopy is critical for patient safety and diagnostic accuracy, yet current methods relying on manual adjustments pose risks of improper insufflation. This study aimed to develop an automated gastric pressure control system for flexible endoscopy, addressing these challenges with a piezoresistive pressure sensor that can be integrated into a 7.3 mm diameter flexible endoscope.

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Metformin (MetF) is used worldwide as a first-line therapy for type 2 diabetes. Recently, interest in the pleiotropic effects of MetF, such as its anticancer and antiaging properties, has increased. However, the molecular target of MetF and the detailed mechanism underlying its ability to inhibit cell growth through autophagy induction remain incompletely understood.

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  • Gastroesophageal Reflux Disease (GERD) leads to stomach contents flowing back into the esophagus, which may also affect ear health through the Eustachian tube.
  • A study of over 669,000 South Korean patients found a strong link between GERD and the occurrence of tinnitus, suggesting that the ear issues could be related to reflux problems.
  • However, treating GERD with proton pump inhibitors did not significantly lower the chances of developing tinnitus in these patients.*
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  • There is a need for better methods to optimize nanostructures for enhancing optical devices, as current approaches lack accuracy and efficiency, particularly regarding fabrication tolerance.
  • This study presents an AI-driven optimization strategy using a support vector regression (SVR) model, which effectively predicts the relationship between nanograting structures and their transmittance with high precision.
  • Experimental results demonstrated that the optimized nanograting structure significantly improved the performance of devices like OLEDs and OSCs, achieving a 17% increase in external quantum efficiency and a 10.7% boost in power-conversion efficiency.
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The array of complex and evolving patient data has limited clinical decision making in the emergency department (ED). This study introduces an advanced deep learning algorithm designed to enhance real-time prediction accuracy for integration into a novel Clinical Decision Support System (CDSS). A retrospective study was conducted using data from a level 1 tertiary hospital.

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Immunohistochemistry (IHC) is the common companion diagnostics in targeted therapies. However, quantifying protein expressions in IHC images present a significant challenge, due to variability in manual scoring and inherent subjective interpretation. Deep learning (DL) offers a promising approach to address these issues, though current models require extensive training for each cancer and IHC type, limiting the practical application.

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Biological age is an indicator of whether an individual is experiencing rapid, slowing, or normal aging. Perceived age is highly correlated with biological age, which reflects health appraisal and is often used as a clinical marker of aging. Perceived age has been reported as an important indicator of biological age and general health status, not only in older adult populations but also in young and middle-aged adults.

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  • The GM(1,1) model is popular for its low sample and computational requirements but often struggles with prediction accuracy despite good fitting results.
  • This paper introduces an enhanced GM(1,1) model, called OB-WMSE-GM(1,1), which focuses on improving predictive accuracy through a weighted mean squared error approach.
  • The new model outperformed traditional GM(1,1) models in various tests, achieving lower error metrics in simulations and real-world applications, and can further improve when combined with other techniques.
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  • Mono-ubiquitinated PCNA (mono-Ub-PCNA) helps the DNA replication process bypass obstacles and DNA damage but must be de-ubiquitinated to continue accurate DNA synthesis.
  • The protein ATAD5, along with the UAF1-USP1 complex, is responsible for the de-ubiquitination of Ub-PCNA, but the regulation of this process was previously unclear.
  • Research shows that BAZ1B, part of a chromatin-remodeling complex, is critical for controlling Ub-PCNA de-ubiquitination; loss of its interaction with ATAD5 can lead to premature de-ubiquitination and increased sensitivity to oxidative stress.
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Alternating-current electroluminescent fibres are promising candidates as light sources for smart textiles and soft machines. However, physical damage from daily use causes device deterioration or failure, making self-healable electroluminescent fibres attractive. In addition, soft robots could benefit from light-emitting combined with magnetically actuated functions.

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  • Emotion goals, particularly the desire for low arousal positive affect (LAP), can influence a person's emotional experiences and regulate negative states, which is important for individuals with depression.
  • A study involving 50 females with depression used ecological momentary assessment to examine how their momentary desire for different types of positive affect related to their depressive feelings over a week.
  • Findings suggested that a stronger desire for LAP weakened the link between previous and subsequent depressive affect, highlighting the potential benefits of focusing on specific positive emotions in daily life for those experiencing depression.
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