Vertex Augmentation With Hyaluronic Acid Filler: A Novel Technique for Height Enhancement and Cephalic Contouring.

Height augmentation and cephalic contouring using hyaluronic acid (HA) fillers represent an innovative approach in minimally invasive aesthetic medicine. This study introduces a novel technique for vertex augmentation, leveraging cross-linked HA fillers to achieve subtle height enhancement and cephalic contouring. A 42-year-old male patient seeking non-surgical height augmentation underwent vertex injections with 15 ml of HA filler (e.

Oncoplastic breast reconstruction with single-port laparoscopically harvested omental flap: insights from a ten-year tertiary center experience.

Purpose: To evaluate the 10-year functional and oncological outcomes of single-port laparoscopically harvested omental flap (SLOF) for immediate breast reconstruction after breast cancer surgery. The technical feasibility and oncologic safety of breast reconstruction using a laparoscopically harvested omental flap remain controversial.

Methods: We examined 236 patients with breast cancer (including 2 patients with malignant phyllodes tumors) who underwent nipple-sparing mastectomy or breast-conserving surgery followed by immediate SLOF reconstruction between February 2015 and March 2024 at our institution.

Thalassotalea aquiviva sp. nov., and Thalassotalea maritima sp. nov., Isolated from Seawater of the Coast in South Korea.

Two novel bacterial strains, 273M-4 and Sam97, were isolated from seawater in the Yellow Sea, Muan-gun, South Korea, and identified as members of the genus Thalassotalea. Both strains were Gram-stain-negative, aerobic, rod-shaped, non-motile, non-flagellated, and oxidase- and catalase-positive. Phylogenetic analysis based on 16S rRNA gene sequences showed that strains 273M-4 and Sam97 were most closely related to Thalassotalea ponticola KCTC 42155, with sequence similarities of 97.

Characterization of Newly Isolated Bacteriophages Targeting Carbapenem-Resistant Klebsiella pneumoniae.

Klebsiella pneumoniae, a Gram-negative opportunistic pathogen, is increasingly resistant to carbapenems in clinical settings. This growing problem necessitates the development of alternative antibiotics, with phage therapy being one promising option. In this study, we investigated novel phages targeting carbapenem-resistant Klebsiella pneumoniae (CRKP) and evaluated their lytic capacity against clinical isolates of CRKP.

A 2-oxoglutarate-dependent dioxygenase, GLUCORAPHASATIN SYNTHASE 1 (GRS1) is a major determinant for different aliphatic glucosinolates between radish and Chinese cabbage.

Glucosinolates (GSLs) are secondary metabolites in Brassicaceae plants and play a defensive role against a variety of abiotic and biotic stresses. Also, it exhibits anti-cancer activity against cancer cell in human. Different profiles of aliphatic GSL compounds between radish and Chinese cabbage were previously reported.

Association between urgency urinary incontinence and cause-specific mortality: a population-based analysis.

Purpose: Urgency urinary incontinence (UUI) is a prevalent condition with significant implications for quality of life, yet its association with mortality was less examined by a few studies. Using data from representative U.S.

Impact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model.

The increasing use of SARS-CoV-2 mRNA vaccines has raised concerns about their potential toxicological effects, necessitating further investigation to ensure their safety. To address this issue, we aimed to evaluate the toxicological effects of SARS-CoV-2 mRNA vaccine candidates formulated with four different types of lipid nanoparticles in ICR mice, focusing on repeated doses and administration routes. We conducted an extensive analysis in which mice received the mRNA vaccine candidates intramuscularly (50 μg/head) twice at 2-week intervals, followed by necropsy at 2 and 14 dpsi (days post-secondary injection).

The Use of Dynamic Navigation for the Placement of Zygoma Implants: A Cadaver Study to Compare Accuracy.

This study aimed to compare the angular, platform, and apical deviation of zygoma implants placed with the aid of a dynamic navigation (DN) device compared with the implants placed freehand. Eight cadaver heads were used for the study. Preoperative cone beam computerized tomography (CBCT) scans were made for the heads, and an implant-planning software was used to plan zygoma implants bilaterally in each scanned head.

Comparing Large Language Model and Human Reader Accuracy with Image Challenge Case Image Inputs.

Background Application of multimodal large language models (LLMs) with both textual and visual capabilities has been steadily increasing, but their ability to interpret radiologic images is still doubted. Purpose To evaluate the accuracy of LLMs and compare it with that of human readers with varying levels of experience and to assess the factors affecting LLM accuracy in answering Image Challenge cases. Materials and Methods Radiologic images of cases from October 13, 2005, to April 18, 2024, were retrospectively reviewed.

Low-Dose CT Screening in East Asian Women Who Have Never Smoked: Association between Family History of Lung Cancer and Ground-Glass Nodule Prevalence and Growth.

Background Characteristics of ground-glass nodules (GGNs) in Asian women who have never smoked with family history of lung cancer (FHLC) remain unexamined. Purpose To investigate the differences in GGN progression to lung cancer at low-dose CT (LDCT) screening between Asian women who have never smoked with and without FHLC, and to examine associations between FHLC and GGN prevalence and growth. Materials and Methods This single-center retrospective study included East Asian women who had never smoked and had no personal history of lung cancer who underwent baseline LDCT for a health checkup between January 2011 and December 2015.

A novel high frequency, high bandwidth, three phase Mach-Zehnder optical data link.

In inertial confinement fusion, hydrogen isotopes are fused together under high pressures and temperatures. Typically, the duration of these experiments is incredibly short, on the order of around 60-150 ps. Due to the high radiation environment, a detector's signal is typically data linked far distances to a protected location.

Whole genome sequence of a M64 isolate harboring extensive deletions, including the -containing region.

Clinical isolates of M64 strain from South Korea lack the gene, which is associated with isoniazid resistance. Herein, we report the whole genome sequence of M64, with genomic coverage of 2,791× and a genome size of 4,353,699 bp.

The pattern of the distribution of incompetent segments within the great saphenous vein at C2 lower extremity: A report conforming to the 2024 IAC standards and guidelines.

Objectives: To analyze the distribution of incompetent segments in the great saphenous vein (GSV) in Clinical, Etiological, Anatomical, Pathophysiological (CEAP) classification C2 limbs to provide a reference for appropriate diagnosis and treatment planning.

Methods: We analyzed the distributions of incompetent segments in the GSVs of the C2 lower extremity undergoing duplex ultrasound from September 2017 to December 2023. The examined segments were the saphenofemoral junction (SFJ), GSV at the proximal thigh, GSV at the knee, and GSV below the knee.

Role of Minimally Invasive Reoperation for Postoperatively Diagnosed T2 Gallbladder Cancer: Multicenter Retrospective Cohort Study.

Background: Although T2 gallbladder cancer (GBC) incidentally diagnosed after cholecystectomy requires additional resection, the surgical approaches are technically difficult due to inflammatory adhesion or fibrosis around the hepatoduodenal ligament and gallbladder bed. In this study, we sought to compare the surgical and oncologic outcomes of open and minimally invasive reoperation for postoperatively diagnosed T2 GBC.

Study Design: Patients who underwent open (n = 110) and laparoscopic (n = 38) reoperation for T2 GBC between November 2004 and October 2022 at five tertiary referral centers were included in this multicenter retrospective cohort study.

Response Rates, Reliability, and Convergent Validity in Experience Sampling Data.

This study examined associations of compliance rate with the reliability and convergent validity of intoxication and negative affect assessments in experience sampling method (ESM) data in three samples (Veterans, Sexual Minority Men, and College Students). Convergent validity was operationalized as within-person associations between daily aggregates of random in situ assessments and retrospective daily assessments or transdermal alcohol assessments. Measures with lower ICC require more assessments for a reliable aggregate (e.

Validation of the Korean version of inflammatory Rasch-built Overall Disability Scale in patients with inflammatory neuropathy.

Background And Aims: The Inflammatory Rasch-built Overall Disability Scale (I-RODS) is an effective activity measure for use in inflammatory peripheral neuropathy. The aim of this study was to validate the Korean version of the I-RODS in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), Guillain-Barré syndrome (GBS), anti-myelin-associated glycoprotein (MAG) neuropathy, and autoimmune nodopathy.

Methods: A total of 120 patients underwent clinical evaluations, which included the I-RODS, Inflammatory Neuropathy Cause and Treatment (INCAT) assessment, and Jamar grip strength (kg) measurement.

Periodontal stability and treatment needs in patients under antiresorptive therapy during supportive periodontal care: a retrospective case-control study.

Objectives: This study aimed to investigate periodontal stability and treatment needs in patients under antiresorptive therapy (ART) during supportive periodontal care (SPC), with a focus on medication-related osteonecrosis of the jaw (MRONJ) risk and reasons for tooth loss.

Method And Materials: In this retrospective case-control study, records of 100 stage III/IV SPC patients (50 ART-exposed, 50 unexposed) were analyzed for probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), history of periodontal surgery, tooth loss and MRONJ risk over a period of up to 15 years after active periodontal therapy.

Results: Baseline patient characteristics were similar between ART-exposed and unexposed patients.

Isosteric 3D Bicyclo[1.1.1]Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing.

Lipid nanoparticles (LNPs) are an essential component of messenger RNA (mRNA) vaccines and genome editing therapeutics. Ionizable amino lipids, which play the most crucial role in enabling mRNA to overcome delivery barriers, have, to date, been restricted to two-dimensional (2D) architectures. Inspired by improved physicochemical properties resulting from the incorporation of three-dimensionality (3D) into small-molecule drugs, we report the creation of 3D ionizable lipid designs through the introduction of bicyclo[1.

A propensity score-adjusted HRV analysis of social avoidance and distress in patients with panic disorders.

Panic disorder (PD) may accompany elevated social avoidance and distress (SAD). Higher SAD in patients with PD predicts a poorer prognosis and response to treatment. As heart rate variability (HRV) reflects the self-regulatory capacity underlying SAD, applying HRV to distinguish PD heterogeneity would be clinically beneficial in formulating personalized treatment strategies.

Crucial Role of c-Myc/Monocarboxylate Transporter 4 Signaling in Capsaicin Induced Apoptotic and Anti-Warburg Effects in Hepatocellular Carcinoma.

Though Capsaicin from chili peppers was known to have antitumor effects in several cancers, the underlying antitumor pathogenesis of Capsaicin is not clear to date. Thus, the antitumor mechanism of Capsaicin was explored in Hep3B and Huh7 hepatocellular carcinoma (HCC) cells in relation to c-Myc/monocarboxylate transporter 4 (MCT4) signaling. To elucidate the antitumor mechanism of capsaicin, cytotoxicity assay, cell cycle analysis, Western blotting, RT-qPCR, RNA interference, ELISA, immunoprecipitation, and mouse xenograft model were used in this work.