Publications by authors named "Siavash Ghazi"

Article Synopsis
  • Acromegaly caused by extra-pituitary tumors secreting growth hormone releasing hormone (GHRH) is rare, with a new case linked to a mediastinal paraganglioma being reported.
  • A review of 99 patients highlights that most ectopic GHRH secretion typically comes from neuroendocrine tumors in the lung and pancreas.
  • Effective management includes surgical removal of the primary tumor to normalize biochemical levels, and possibly using somatostatin analogs, emphasizing the need for early diagnosis to prevent serious health issues.
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Parathyroid hormone-related protein producing pancreatic neuroendocrine tumors have been infrequently reported. Herein, we report a case of an Iranian woman who had such a tumor during pregnancy, and gave birth to a female neonate with esophago-tracheal fistula and imperforated anus. Hypercalcemia was diagnosed at postpartum because of elevated serum calcium levels in the neonate and neurologic deterioration of the mother.

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Objective: To present an Iranian patient with a nonclassic form of multiple endocrine neoplasia type 1 (MEN 1) who presented with ectopic Cushing syndrome (CS) secondary to a corticotropin (ACTH)-producing thymic neuroendocrine tumor (NET), recurrent renal stones, and a giant cell granuloma of the jaw due to primary hyperparathyroidism (PHPT) without involvement of the pituitary or pancreas.

Methods: Relevant imaging and hormonal evaluations were performed. The patient was operated on 2 occasions for a thymic NET and on 3 occasions for PHPT.

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Introduction: Hypercalcemia is the major electrolyte abnormality in patients with malignant tumors. It can be due to localized osteolytic hypercalcemia or elaboration of humoral substances such as parathyroid hormone-related protein from tumoral cells. In hematological malignancies, a third mechanism of uncontrolled synthesis and secretion of 1-25(OH)2D3 from tumoral cells or neighboring macrophages may contribute to the problem.

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