Publications by authors named "Sian L Baker"
The endothelial glycocalyx (eGlx) constitutes the first barrier to protein in all blood vessels. This is particularly noteworthy in the renal glomerulus, an ultrafiltration barrier. Leakage of protein, such as albumin, across glomerular capillaries results in albumin in the urine (albuminuria).
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- Elevated VEGF A levels contribute to glomerular endothelial cell dysfunction and albuminuria in diabetic nephropathy, suggesting a need for protective strategies.
- The study tested VEGFC as a counteractive agent to VEGFA, finding that it significantly reduced albumin permeability and preserved glomerular function in experimental settings.
- Results indicate that VEGFC may offer a promising therapeutic pathway by reducing diabetic nephropathy progression and maintaining endothelial barrier integrity.